Literature DB >> 2024975

Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis.

T Yokota1, S Mochizuki, K Konno, S Mori, S Shigeta, E De Clercq.   

Abstract

By using an assay system based on a human hepatoblastoma cell line (HB611) that continuously synthesizes hepatitis B virus DNA, the following compounds were found to inhibit hepatitis B virus DNA synthesis at concentrations that were significantly lower than their minimum cytotoxic concentrations: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(phosphonylmethoxyethyl)adenine, 2',3'-dideoxy-2',3'-didehydrocytidine, and 2',3'-dideoxycytidine. The most potent compound was PMEDAP (50% effective concentration, 0.02 micrograms/ml). The selective index, or ratio of the 50% cytotoxic concentration to 50% effective concentration, of PMEDAP was greater than 750.

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Year:  1991        PMID： 2024975      PMCID： PMC245016          DOI： 10.1128/AAC.35.2.394

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Authors:  J C Lin; E DeClercq; J S Pagano
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

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Journal:  Mol Pharmacol       Date:  1987-10       Impact factor: 4.436

3.  Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.

Authors:  T S Lin; R F Schinazi; M S Chen; E Kinney-Thomas; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1987-02-01       Impact factor: 5.858

4.  Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.

Authors:  T S Lin; R F Schinazi; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1987-09-01       Impact factor: 5.858

5.  Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

Authors:  M Baba; R Pauwels; P Herdewijn; E De Clercq; J Desmyter; M Vandeputte
Journal:  Biochem Biophys Res Commun       Date:  1987-01-15       Impact factor: 3.575

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8.  Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro.

Authors:  S Shigeta; K Konno; T Yokota; K Nakamura; E De Clercq
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Journal:  Biochem Biophys Res Commun       Date:  1988-07-15       Impact factor: 3.575
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7.  Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Authors:  S L Doong; C H Tsai; R F Schinazi; D C Liotta; Y C Cheng
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