Literature DB >> 202398

The binding site on SV40 DNA for a T antigen-related protein.

R Tjian.   

Abstract

A protein closely related to SV40 T antigen was purified in a biologically active form from cells infected with the defective adenovirus-SV40 hybrid, Ad2+D2. This 107,000 dalton hybrid protein binds and protects a specific portion of SV40 DNA from digestion by pancreatic DNAase I. Hybridization, endonuclease cleavage and pyrimidine tract analysis of the protected fragments reveal that the D2 hybrid protein binds in a sequential manner to tandem recognition sites which lie within a sequence of 120 nucleotides at position 67 near the origin of SV40 replication.

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Year:  1978        PMID： 202398     DOI： 10.1016/0092-8674(78)90147-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  246 in total

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Authors:  G Chen; A Stenlund
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

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Authors:  Grace Chen; Arne Stenlund
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Authors:  A Oppenheim; A T Horowitz
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4.  DNA replication efficiency depends on transcription factor-binding sites.

Authors:  W J Turner; M E Woodworth
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5.  Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity.

Authors:  H J Lin; R H Upson; D T Simmons
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

6.  Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication.

Authors:  I J Mohr; M P Fairman; B Stillman; Y Gluzman
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

7.  Simian virus 40 host range/helper function mutations cause multiple defects in viral late gene expression.

Authors:  T Stacy; M Chamberlain; C N Cole
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

8.  Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene.

Authors:  J Y Zhu; C N Cole
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

9.  Origin auxiliary sequences can facilitate initiation of simian virus 40 DNA replication in vitro as they do in vivo.

Authors:  Z S Guo; C Gutierrez; U Heine; J M Sogo; M L Depamphilis
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

10.  Relationship among location of T-antigen-induced DNA distortion, auxiliary sequences, and DNA replication efficiency.

Authors:  Susan Okuley; Mindy Call; Tara Mitchell; Bugen Hu; Mary E Woodworth
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103
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