AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the first day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-five patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD >or= 18 and TC <or= 2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. Survival analysis showed that MELD >or= 18 combined with TC <or= 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD >or= 18 and TC <or= 2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis. 2010 Baishideng. All rights reserved.
AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the first day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-five patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD >or= 18 and TC <or= 2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. Survival analysis showed that MELD >or= 18 combined with TC <or= 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD >or= 18 and TC <or= 2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis. 2010 Baishideng. All rights reserved.
Authors: Douglas M Heuman; Souheil G Abou-Assi; Adil Habib; Leslie M Williams; R Todd Stravitz; Arun J Sanyal; Robert A Fisher; Anastasios A Mihas Journal: Hepatology Date: 2004-10 Impact factor: 17.425
Authors: Adil Habib; Anastasios A Mihas; Souheil G Abou-Assi; Leslie M Williams; Edith Gavis; W Michael Pandak; Douglas M Heuman Journal: Clin Gastroenterol Hepatol Date: 2005-03 Impact factor: 11.382
Authors: Winston Dunn; Laith H Jamil; Larry S Brown; Russell H Wiesner; W Ray Kim; K V Narayanan Menon; Michael Malinchoc; Patrick S Kamath; Vijay Shah Journal: Hepatology Date: 2005-02 Impact factor: 17.425
Authors: B Angermayr; M Cejna; F Karnel; M Gschwantler; F Koenig; J Pidlich; H Mendel; L Pichler; M Wichlas; A Kreil; M Schmid; A Ferlitsch; E Lipinski; H Brunner; J Lammer; P Ferenci; A Gangl; M Peck-Radosavljevic Journal: Gut Date: 2003-06 Impact factor: 23.059
Authors: László Kalabay; László Gráf; Krisztián Vörös; László Jakab; Zsuzsa Benko; László Telegdy; Béla Fekete; Zoltán Prohászka; George Füst Journal: BMC Gastroenterol Date: 2007-03-29 Impact factor: 3.067
Authors: Mario Uccello; Giulia Malaguarnera; Elisa M Pelligra; Antonio Biondi; Francesco Basile; Massimo Motta Journal: Indian J Med Paediatr Oncol Date: 2011-04
Authors: Adam M Lubert; Tarek Alsaied; Joseph J Palermo; Nadeem Anwar; Elaine M Urbina; Nicole M Brown; Craig Alexander; Hassan Almeneisi; Fred Wu; Andrew R Leventhal; Nael Aldweib; Michael Mendelson; Alexander R Opotowsky Journal: J Am Heart Assoc Date: 2021-03-31 Impact factor: 5.501
Authors: Marcus Höring; Georg Peschel; Jonathan Grimm; Sabrina Krautbauer; Martina Müller; Kilian Weigand; Gerhard Liebisch; Christa Buechler Journal: Int J Mol Sci Date: 2022-08-29 Impact factor: 6.208