Literature DB >> 20238398

Alcoholic liver disease and the gut-liver axis.

Gyongyi Szabo1, Shashi Bala.   

Abstract

Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the inflammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. 2010 Baishideng. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20238398      PMCID： PMC2842523          DOI： 10.3748/wjg.v16.i11.1321

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  124 in total

1.  Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathway.

Authors:  Michael D Wheeler; Ronald G Thurman
Journal:  J Biol Chem       Date:  2002-12-13       Impact factor: 5.157

2.  Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms.

Authors:  A Banan; S Choudhary; Y Zhang; J Z Fields; A Keshavarzian
Journal:  J Pharmacol Exp Ther       Date:  1999-12       Impact factor: 4.030

Review 3.  MD-2.

Authors:  Alberto Visintin; Dimitar B Iliev; Brian G Monks; Kristen A Halmen; Douglas T Golenbock
Journal:  Immunobiology       Date:  2006-07-18       Impact factor: 3.144

4.  Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production.

Authors:  G Szabo; P Mandrekar; L Girouard; D Catalano
Journal:  Alcohol Clin Exp Res       Date:  1996-08       Impact factor: 3.455

5.  Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction.

Authors:  A Banan; J Z Fields; H Decker; Y Zhang; A Keshavarzian
Journal:  J Pharmacol Exp Ther       Date:  2000-09       Impact factor: 4.030

Review 6.  Signalling pathways in alcohol-induced liver inflammation.

Authors:  Pranoti Mandrekar; Gyongyi Szabo
Journal:  J Hepatol       Date:  2009-03-28       Impact factor: 25.083

7.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Authors:  A Poltorak; X He; I Smirnova; M Y Liu; C Van Huffel; X Du; D Birdwell; E Alejos; M Silva; C Galanos; M Freudenberg; P Ricciardi-Castagnoli; B Layton; B Beutler
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

8.  Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion.

Authors:  Istvan Hritz; Arumugam Velayudham; Angela Dolganiuc; Karen Kodys; Pranoti Mandrekar; Evelyn Kurt-Jones; Gyongyi Szabo
Journal:  Hepatology       Date:  2008-10       Impact factor: 17.425

9.  Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats.

Authors:  Ece Mutlu; Ali Keshavarzian; Phillip Engen; Christopher B Forsyth; Masoumeh Sikaroodi; Patrick Gillevet
Journal:  Alcohol Clin Exp Res       Date:  2009-07-23       Impact factor: 3.455

10.  S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model.

Authors:  Amel Karaa; Kyle J Thompson; Iain H McKillop; Mark G Clemens; Laura W Schrum
Journal:  Shock       Date:  2008-08       Impact factor: 3.454
View more
  148 in total

Review 1.  Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients.

Authors:  Gyongyi Szabo; Samir Zakhari
Journal:  World J Gastroenterol       Date:  2011-05-28       Impact factor: 5.742

2.  Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver.

Authors:  Michal Ganz; Timea Csak; Bharath Nath; Gyongyi Szabo
Journal:  World J Gastroenterol       Date:  2011-11-21       Impact factor: 5.742

Review 3.  Mechanisms and cell signaling in alcoholic liver disease.

Authors:  Juliane I Beier; Craig J McClain
Journal:  Biol Chem       Date:  2010-11       Impact factor: 3.915

4.  Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.

Authors:  Yue Wu; Erin L Lousberg; Lachlan M Moldenhauer; John D Hayball; Janet K Coller; Kenner C Rice; Linda R Watkins; Andrew A Somogyi; Mark R Hutchinson
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

5.  Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation.

Authors:  Sanjoy Roychowdhury; Dian J Chiang; Palash Mandal; Megan R McMullen; Xiuli Liu; Jessica I Cohen; John Pollard; Ariel E Feldstein; Laura E Nagy
Journal:  Alcohol Clin Exp Res       Date:  2012-01-24       Impact factor: 3.455

6.  Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.

Authors:  Yuhua Wang; Yanlong Liu; Anju Sidhu; Zhenhua Ma; Craig McClain; Wenke Feng
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-04-26       Impact factor: 4.052

7.  Design and rationale of a multicenter defeat alcoholic steatohepatitis trial: (DASH) randomized clinical trial to treat alcohol-associated hepatitis.

Authors:  Srinivasan Dasarathy; Mack C Mitchell; Bruce Barton; Craig J McClain; Gyongyi Szabo; Laura E Nagy; Svetlana Radaeva; Arthur J McCullough
Journal:  Contemp Clin Trials       Date:  2020-07-31       Impact factor: 2.226

8.  Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha.

Authors:  Veronica L Massey; Lauren G Poole; Deanna L Siow; Edilson Torres; Nikole L Warner; Robin H Schmidt; Jeffrey D Ritzenthaler; Jesse Roman; Gavin E Arteel
Journal:  Alcohol Clin Exp Res       Date:  2015-09-18       Impact factor: 3.455

9.  Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol.

Authors:  Irina A Kirpich; Wenke Feng; Yuhua Wang; Yanlong Liu; Juliane I Beier; Gavin E Arteel; K Cameron Falkner; Shirish S Barve; Craig J McClain
Journal:  Alcohol       Date:  2013-02-26       Impact factor: 2.405

10.  Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.

Authors:  Andressa Franca; Antonio Carlos Melo Lima Filho; Mateus T Guerra; Jittima Weerachayaphorn; Marcone Loiola Dos Santos; Basile Njei; Marie Robert; Cristiano Xavier Lima; Paula Vieira Teixeira Vidigal; Jesus M Banales; Meenakshisundaram Ananthanarayanam; M Fatima Leite; Michael H Nathanson
Journal:  Hepatology       Date:  2018-12-31       Impact factor: 17.425
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.