Literature DB >> 20237748

[Organization of clinical research: in general and visceral surgery].

M Schneider1, J Werner, J Weitz, M W Büchler.   

Abstract

The structural organization of research facilities within a surgical university center should aim at strengthening the department's research output and likewise provide opportunities for the scientific education of academic surgeons. We suggest a model in which several independent research groups within a surgical department engage in research projects covering various aspects of surgically relevant basic, translational or clinical research. In order to enhance the translational aspects of surgical research, a permanent link needs to be established between the department's scientific research projects and its chief interests in clinical patient care. Importantly, a focus needs to be placed on obtaining evidence-based data to judge the efficacy of novel diagnostic and treatment concepts. Integration of modern technologies from the fields of physics, computer science and molecular medicine into surgical research necessitates cooperation with external research facilities, which can be strengthened by coordinated support programs offered by research funding institutions.

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Year:  2010        PMID: 20237748     DOI: 10.1007/s00104-009-1834-5

Source DB:  PubMed          Journal:  Chirurg        ISSN: 0009-4722            Impact factor:   0.955


  21 in total

1.  Development of a navigation system for minimally invasive esophagectomy.

Authors:  H G Kenngott; J Neuhaus; B P Müller-Stich; I Wolf; M Vetter; H-P Meinzer; J Köninger; M W Büchler; C N Gutt
Journal:  Surg Endosc       Date:  2007-12-20       Impact factor: 4.584

2.  Coordinating a national clinical trials center: the German experience.

Authors:  Christoph M Seiler; Markus K Diener; Nuh Rahbari; Hartwig Bauer; Matthias Rothmund; Markus W Büchler
Journal:  Surgery       Date:  2009-04-19       Impact factor: 3.982

Review 3.  Tetraspanins: push and pull in suppressing and promoting metastasis.

Authors:  Margot Zöller
Journal:  Nat Rev Cancer       Date:  2008-12-11       Impact factor: 60.716

4.  Laparoscopic mesh-augmented hiatoplasty as a method to treat gastroesophageal reflux without fundoplication: single-center experience with 306 consecutive patients.

Authors:  Beat P Müller-Stich; Jörg Köninger; Bettina H Müller-Stich; Fritz Schäfer; René Warschkow; Arianeb Mehrabi; Carsten N Gutt
Journal:  Am J Surg       Date:  2009-01-29       Impact factor: 2.565

5.  Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

Authors:  G Kallifatidis; V Rausch; B Baumann; A Apel; B M Beckermann; A Groth; J Mattern; Z Li; A Kolb; G Moldenhauer; P Altevogt; T Wirth; J Werner; P Schemmer; M W Büchler; A V Salnikov; I Herr
Journal:  Gut       Date:  2008-10-01       Impact factor: 23.059

6.  Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis.

Authors:  Michael Kremer; Ashley W Perry; Richard J Milton; Richard A Rippe; Michael D Wheeler; Ian N Hines
Journal:  Hepatology       Date:  2008-01       Impact factor: 17.425

7.  Abnormal crosstalk between pancreatic acini and macrophages during the clearance of apoptotic cells in chronic pancreatitis.

Authors:  M Bartel; G M Hänsch; T Giese; R Penzel; Go Ceyhan; K Ketterer; M von Knebel-Döberitz; H M Friess; N A Giese
Journal:  J Pathol       Date:  2008-06       Impact factor: 7.996

8.  Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalence trial (POVATI: ISRCTN60734227).

Authors:  Christoph M Seiler; Andreas Deckert; Markus K Diener; Hanns-Peter Knaebel; Markus A Weigand; Norbert Victor; Markus W Büchler
Journal:  Ann Surg       Date:  2009-06       Impact factor: 12.969

9.  Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy.

Authors:  Anja Apel; Ingrid Herr; Heinz Schwarz; H Peter Rodemann; Andreas Mayer
Journal:  Cancer Res       Date:  2008-03-01       Impact factor: 12.701

10.  Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib versus TACE plus placebo in patients with hepatocellular cancer before liver transplantation - HeiLivCa [ISRCTN24081794].

Authors:  K Hoffmann; H Glimm; B Radeleff; G Richter; C Heining; I Schenkel; A Zahlten-Hinguranage; P Schirrmacher; J Schmidt; M W Büchler; D Jaeger; C von Kalle; P Schemmer
Journal:  BMC Cancer       Date:  2008-11-26       Impact factor: 4.430

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  2 in total

1.  How to ensure the survival of the surgeon-scientist? The Homburg Program.

Authors:  Michael D Menger; Martin K Schilling; Hans-Joachim Schäfers; Tim Pohlemann; Matthias W Laschke
Journal:  Langenbecks Arch Surg       Date:  2012-02-24       Impact factor: 3.445

2.  Future perspectives for surgical research in Germany.

Authors:  Markus K Diener; Michael D Menger; Joachim Jähne; Hans-Detlev Saeger; Ernst Klar
Journal:  Langenbecks Arch Surg       Date:  2014-03-11       Impact factor: 3.445

  2 in total

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