UNLABELLED: PET is an important functional imaging technique that can be used to investigate neurotransmitter receptors and transporters directly by mapping human brain function. PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. METHODS: This review focuses on the use of PET tracers and kinetic modeling in identifying regional brain abnormalities and regions associated with cognitive functioning in schizophrenia. A variety of PET tracers have been used to identify brain abnormalities, including (11)C, (15)O-water, (18)F-fallypride, and L-3,4-dihydroxy-6-(18)F-fluorophenylalanine ((18)F-FDOPA). RESULTS: Some studies have used compartmental modeling to determine tracer binding kinetics. The most consistent findings show a difference in the dopamine content in the prefrontal cortex, anterior cingulate gyrus, and hippocampus between healthy controls and patients with schizophrenia. Studies also show a higher density of D(2) receptors in the striatum and neural brain dysconnectivity. CONCLUSION: Future investigations integrating clinical, imaging, genetic, and cognitive aspects are warranted to gain a better understanding of the pathophysiology of this disorder.
UNLABELLED: PET is an important functional imaging technique that can be used to investigate neurotransmitter receptors and transporters directly by mapping human brain function. PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. METHODS: This review focuses on the use of PET tracers and kinetic modeling in identifying regional brain abnormalities and regions associated with cognitive functioning in schizophrenia. A variety of PET tracers have been used to identify brain abnormalities, including (11)C, (15)O-water, (18)F-fallypride, and L-3,4-dihydroxy-6-(18)F-fluorophenylalanine ((18)F-FDOPA). RESULTS: Some studies have used compartmental modeling to determine tracer binding kinetics. The most consistent findings show a difference in the dopamine content in the prefrontal cortex, anterior cingulate gyrus, and hippocampus between healthy controls and patients with schizophrenia. Studies also show a higher density of D(2) receptors in the striatum and neural brain dysconnectivity. CONCLUSION: Future investigations integrating clinical, imaging, genetic, and cognitive aspects are warranted to gain a better understanding of the pathophysiology of this disorder.
Authors: Dinesh K Shukla; Joshua John Chiappelli; Hemalatha Sampath; Peter Kochunov; Stephanie M Hare; Krista Wisner; Laura M Rowland; L Elliot Hong Journal: Schizophr Bull Date: 2019-09-11 Impact factor: 9.306
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Authors: Vattoly J Majo; Matthew S Milak; Jaya Prabhakaran; Pratap Mali; Lyudmila Savenkova; Norman R Simpson; J John Mann; Ramin V Parsey; J S Dileep Kumar Journal: Bioorg Med Chem Date: 2013-06-12 Impact factor: 3.641
Authors: Nora S Vyas; Yohan Lee; Kwangmi Ahn; Andrew Ternouth; Daniel R Stahl; Ammar Al-Chalabi; John F Powell; Basant K Puri Journal: Aging Dis Date: 2012-06-30 Impact factor: 6.745
Authors: Amber Edinoff; Natalie Wu; Charles deBoisblanc; Catherine Olivia Feltner; Mariah Norder; Vesela Tzoneva; Adam M Kaye; Elyse M Cornett; Alan D Kaye; Omar Viswanath; Ivan Urits Journal: Psychopharmacol Bull Date: 2020-09-14