Literature DB >> 20236828

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.

John B Bremner1, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Dorothy M David, Mark Robertson, Kittiya Somphol, Dean Baylis, Jonathan A Coates, John Deadman, Darshini Jeevarajah, David I Rhodes.   

Abstract

An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE). Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20236828     DOI： 10.1016/j.bmc.2010.02.033

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Design and conformational analysis of peptoids containing N-hydroxy amides reveals a unique sheet-like secondary structure.

Authors:  J Aaron Crapster; Joseph R Stringer; Ilia A Guzei; Helen E Blackwell
Journal:  Biopolymers       Date:  2011       Impact factor: 2.505

2.  Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.

Authors:  John B Bremner; Paul A Keller; Stephen G Pyne; Mark J Robertson; K Sakthivel; Kittiya Somphol; Dean Baylis; Jonathan A Coates; John Deadman; Dharshini Jeevarajah; David I Rhodes
Journal:  Beilstein J Org Chem       Date:  2012-08-09       Impact factor: 2.883
  2 in total

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