BACKGROUND: Persistent idiopathic facial pain (PIFP) is defined as a persistent, unilateral facial pain, not associated with sensory loss or other physical signs and with no obvious structural abnormalities that would sufficiently explain pain experience. OBJECTIVE: We were interested whether there is evidence of altered brain morphology in patients with PIFP as it has been described in other chronic pain conditions. METHODS: Using voxel-based morphometry we investigated regional gray matter volume in 11 PIFP patients and 11 age- and sex-matched healthy controls. Furthermore we calculated lateralization indices (LI) to investigate differences in interhemispheric gray matter asymmetries. RESULTS: We report a decrease in gray matter volume in the left anterior cingulate gyrus and left temporo-insular region, as well as in the left and right sensory-motor area, projecting to the representational area of the face. Analyses of LI values demonstrated an increased rightward asymmetry in the middle-anterior insular cortex in patients in comparison with healthy controls. CONCLUSION: Our data support previous findings showing that chronic pain states are display-altered brain morphology in brain regions know to be part of the pain system.
BACKGROUND: Persistent idiopathic facial pain (PIFP) is defined as a persistent, unilateral facial pain, not associated with sensory loss or other physical signs and with no obvious structural abnormalities that would sufficiently explain pain experience. OBJECTIVE: We were interested whether there is evidence of altered brain morphology in patients with PIFP as it has been described in other chronic pain conditions. METHODS: Using voxel-based morphometry we investigated regional gray matter volume in 11 PIFP patients and 11 age- and sex-matched healthy controls. Furthermore we calculated lateralization indices (LI) to investigate differences in interhemispheric gray matter asymmetries. RESULTS: We report a decrease in gray matter volume in the left anterior cingulate gyrus and left temporo-insular region, as well as in the left and right sensory-motor area, projecting to the representational area of the face. Analyses of LI values demonstrated an increased rightward asymmetry in the middle-anterior insular cortex in patients in comparison with healthy controls. CONCLUSION: Our data support previous findings showing that chronic pain states are display-altered brain morphology in brain regions know to be part of the pain system.
Authors: Song Cao; Bangyong Qin; Yi Zhang; Jie Yuan; Bao Fu; Peng Xie; Ganjun Song; Ying Li; Tian Yu Journal: Am J Transl Res Date: 2018-01-15 Impact factor: 4.060
Authors: Nichole M Emerson; Fadel Zeidan; Oleg V Lobanov; Morten S Hadsel; Katherine T Martucci; Alexandre S Quevedo; Christopher J Starr; Hadas Nahman-Averbuch; Irit Weissman-Fogel; Yelena Granovsky; David Yarnitsky; Robert C Coghill Journal: Pain Date: 2013-12-11 Impact factor: 6.961
Authors: Rachel F Smallwood; Angela R Laird; Amy E Ramage; Amy L Parkinson; Jeffrey Lewis; Daniel J Clauw; David A Williams; Tobias Schmidt-Wilcke; Michael J Farrell; Simon B Eickhoff; Donald A Robin Journal: J Pain Date: 2013-05-17 Impact factor: 5.820
Authors: Min Guan; Lijia Ma; Li Li; Bin Yan; Lu Zhao; Li Tong; Shewei Dou; Linjie Xia; Meiyun Wang; Dapeng Shi Journal: PLoS One Date: 2015-04-07 Impact factor: 3.240