Literature DB >> 20236105

Association study of four key folliculogenesis genes in polycystic ovary syndrome.

K Sproul1, M R Jones, R Mathur, R Azziz, M O Goodarzi.   

Abstract

Polycystic ovaries and impaired fertility are the result of abnormal folliculogenesis. Our objective was to determine the role of four candidate folliculogenesis genes in the development of polycystic ovary syndrome (PCOS). Women with and without PCOS (335 cases; 198 controls) were genotyped for single nucleotide polymorphisms in GDF9, BMP15, AMH, and AMHR2. Variants in these genes were not associated with PCOS. Certain GDF9 variants were associated with hirsutism scores and parity in PCOS patients. GDF9 may thus serve as a modifier gene. These results suggest that inherited defects in folliculogenesis are not major factors in the genetic susceptibility to PCOS.

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Year:  2010        PMID： 20236105      PMCID： PMC3085028          DOI： 10.1111/j.1471-0528.2010.02527.x

Source DB:  PubMed          Journal:  BJOG        ISSN： 1470-0328            Impact factor:   6.531


  11 in total

1.  Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome.

Authors:  Fabio Lopes Teixeira Filho; Edmund Chada Baracat; Taek Hoo Lee; Chang Suk Suh; Motozumi Matsui; R Jeffrey Chang; Shunichi Shimasaki; Gregory F Erickson
Journal:  J Clin Endocrinol Metab       Date:  2002-03       Impact factor: 5.958

2.  Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries.

Authors:  Laura Pellatt; Laurine Hanna; Mark Brincat; Ray Galea; Henrietta Brain; Saffron Whitehead; Helen Mason
Journal:  J Clin Endocrinol Metab       Date:  2006-10-24       Impact factor: 5.958

3.  Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

Authors:  Y Mishina; R Rey; M J Finegold; M M Matzuk; N Josso; R L Cate; R R Behringer
Journal:  Genes Dev       Date:  1996-10-15       Impact factor: 11.361

4.  Mutation analysis of the growth differentiation factor-9 and -9B genes in patients with premature ovarian failure and polycystic ovary syndrome.

Authors:  K Takebayashi; K Takakura; H Wang; F Kimura; K Kasahara; Y Noda
Journal:  Fertil Steril       Date:  2000-11       Impact factor: 7.329

5.  Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.

Authors:  C Yan; P Wang; J DeMayo; F J DeMayo; J A Elvin; C Carino; S V Prasad; S S Skinner; B S Dunbar; J L Dube; A J Celeste; M M Matzuk
Journal:  Mol Endocrinol       Date:  2001-06

6.  Anti-müllerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries.

Authors:  Sharron A Stubbs; Kate Hardy; Patricia Da Silva-Buttkus; Jaroslav Stark; Lisa J Webber; Adrienne M Flanagan; Axel P N Themmen; Jenny A Visser; Nigel P Groome; Stephen Franks
Journal:  J Clin Endocrinol Metab       Date:  2005-07-19       Impact factor: 5.958

7.  Anti-Mullerian hormone, its receptor, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome.

Authors:  Sophie Catteau-Jonard; Soazik P Jamin; Arnaud Leclerc; Jacques Gonzalès; Didier Dewailly; Nathalie di Clemente
Journal:  J Clin Endocrinol Metab       Date:  2008-08-12       Impact factor: 5.958

8.  A functional anti-mullerian hormone gene polymorphism is associated with follicle number and androgen levels in polycystic ovary syndrome patients.

Authors:  Marlies E Kevenaar; Joop S E Laven; Sharon Lie Fong; André G Uitterlinden; Frank H de Jong; Axel P N Themmen; Jenny A Visser
Journal:  J Clin Endocrinol Metab       Date:  2008-01-29       Impact factor: 5.958

9.  The prevalence and features of the polycystic ovary syndrome in an unselected population.

Authors:  Ricardo Azziz; Keslie S Woods; Rosario Reyna; Timothy J Key; Eric S Knochenhauer; Bulent O Yildiz
Journal:  J Clin Endocrinol Metab       Date:  2004-06       Impact factor: 5.958

10.  Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome.

Authors:  Alejandro Gónzalez; Reposo Ramírez-Lorca; Carmen Calatayud; Nicolás Mendoza; Agustín Ruiz; Maria Eugenia Sáez; Francisco Jesús Morón
Journal:  Fertil Steril       Date:  2007-10-01       Impact factor: 7.329
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  13 in total

Review 1.  Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function.

Authors:  Livio Casarini; Elisa Pignatti; Manuela Simoni
Journal:  Rev Endocr Metab Disord       Date:  2011-12       Impact factor: 6.514

2.  Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles.

Authors:  Almudena Veiga-Lopez; Wen Ye; Vasantha Padmanabhan
Journal:  Fertil Steril       Date:  2012-01-14       Impact factor: 7.329

Review 3.  Polycystic ovary syndrome.

Authors:  Zi-Jiang Chen; Yuhua Shi
Journal:  Front Med China       Date:  2010-08-12

Review 4.  The role of TGF-β in polycystic ovary syndrome.

Authors:  Nazia Raja-Khan; Margrit Urbanek; Raymond J Rodgers; Richard S Legro
Journal:  Reprod Sci       Date:  2013-04-12       Impact factor: 3.060

5.  Anti-Müllerian hormone gene polymorphism is associated with androgen levels in Chinese polycystic ovary syndrome patients with insulin resistance.

Authors:  Meng-Xue Zheng; Yan Li; Rong Hu; Fei-Miao Wang; Xiao-Mei Zhang; Bing Guan
Journal:  J Assist Reprod Genet       Date:  2016-01-06       Impact factor: 3.412

6.  Increased frequency of the anti-mullerian-inhibiting hormone receptor 2 (AMHR2) 482 A>G polymorphism in women with polycystic ovary syndrome: relationship to luteinizing hormone levels.

Authors:  Neoklis A Georgopoulos; Eleni Karagiannidou; Vasiliki Koika; Nikolaos D Roupas; Anastasia Armeni; Dimitra Marioli; Efstathios Papadakis; C K Welt; Dimitrios Panidis
Journal:  J Clin Endocrinol Metab       Date:  2013-08-22       Impact factor: 5.958

Review 7.  Genetic defects of ovarian TGF-β-like factors and premature ovarian failure.

Authors:  L Persani; R Rossetti; C Cacciatore; S Fabre
Journal:  J Endocrinol Invest       Date:  2011-02-04       Impact factor: 4.256

8.  Intrafollicular Concentrations of the Oocyte-secreted Factors GDF9 and BMP15 Vary Inversely in Polycystic Ovaries.

Authors:  Stine Gry Kristensen; Ajay Kumar; Linn Salto Mamsen; Bhanu Kalra; Susanne Elisabeth Pors; Jane Alrø Bøtkjær; Kirsten Tryde Macklon; Jens Fedder; Erik Ernst; Kate Hardy; Stephen Franks; Claus Yding Andersen
Journal:  J Clin Endocrinol Metab       Date:  2022-07-14       Impact factor: 6.134

9.  A Major Gene for Bovine Ovulation Rate.

Authors:  Brian W Kirkpatrick; Chris A Morris
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

10.  Mutation analysis of exon1 of bone morphogenetic protein-15 gene in Iranian patients with polycystic ovarian syndrome.

Authors:  Anahita Mehdizadeh; Mohammad Hasan Sheikhha; Seyed Mehdi Kalantar; Bibi Shahnaz Aali; Azam Ghanei
Journal:  Int J Reprod Biomed (Yazd)       Date:  2016-08
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