| Literature DB >> 20236080 |
Guizhi Xiao1, Hao Fang, Chengguo Xing, Wenfang Xu.
Abstract
Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.Entities:
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Year: 2009 PMID： 20236080 DOI： 10.2174/138955709791012238
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862