| Literature DB >> 2023522 |
N Miyawaki1, T Furuta, T Shigei, H Yamauchi, T Iso.
Abstract
The cardiovascular effects of SD-3211, a novel benzothiazine Ca++ channel blocker, were compared with those of diltiazem and nicardipine in Langendorff-perfused rabbit hearts. SD-3211 was more potent in increasing coronary artery flow than in depressing cardiac function (i.e., contractile force, heart rate and conduction time). The relative specificity of SD-3211 for coronary vasodilation to cardiodepression was clearly greater than that of diltiazem, but less than that of nicardipine. Thus, the present study demonstrates that SD-3211, despite a non-dihydropyridine type of Ca++ channel blocker, can be characterized as a potent coronary vasodilator with a little effect on cardiac function.Entities:
Mesh：
Substances：
Year: 1991 PMID： 2023522 DOI： 10.1016/0024-3205(91)90222-w
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037