J H Lee1, I J Choi, M C Kook, B-H Nam, Y-W Kim, K W Ryu. 1. Gastric Cancer Branch, Research Institute for National Cancer Control and Evaluation, National Cancer Centre, Goyang-si, Gyeonggi-do, Korea.
Abstract
BACKGROUND: Early gastric cancer with signet ring cell histology has been reported as a favourable histological type. The aim of this study was to identify risk factors associated with lymph node metastasis in patients with this type of early gastric cancer. METHODS: A cross-sectional study of patients with early gastric cancer with differentiated and signet ring cell histology undergoing surgery was conducted. Risk factors were evaluated using multiple logistic regression analysis with odds ratios and 95 per cent confidence intervals. RESULTS: In 1362 patients undergoing gastrectomy for early gastric cancer, the rate of lymph node metastasis was similar for tumours with signet ring cell and differentiated histological findings (10.7 versus 9.0 per cent respectively; P = 0.307). Logistic regression analysis showed that depth of tumour invasion was predictive of lymph node metastasis in patients with signet ring cell histology (P < 0.001). Tumour size was not associated with lymph node metastasis in either univariable or multivariable analysis. Lesions smaller than 2 cm were not uncommon in patients with signet ring cell gastric tumours and lymph node metastases (six of 48; 13 per cent). CONCLUSION: Patients with early gastric cancer with signet ring cell-type histology are probably best treated by gastrectomy with lymph node dissection. Copyright 2010 British Journal of Surgery Society Ltd.
BACKGROUND: Early gastric cancer with signet ring cell histology has been reported as a favourable histological type. The aim of this study was to identify risk factors associated with lymph node metastasis in patients with this type of early gastric cancer. METHODS: A cross-sectional study of patients with early gastric cancer with differentiated and signet ring cell histology undergoing surgery was conducted. Risk factors were evaluated using multiple logistic regression analysis with odds ratios and 95 per cent confidence intervals. RESULTS: In 1362 patients undergoing gastrectomy for early gastric cancer, the rate of lymph node metastasis was similar for tumours with signet ring cell and differentiated histological findings (10.7 versus 9.0 per cent respectively; P = 0.307). Logistic regression analysis showed that depth of tumour invasion was predictive of lymph node metastasis in patients with signet ring cell histology (P < 0.001). Tumour size was not associated with lymph node metastasis in either univariable or multivariable analysis. Lesions smaller than 2 cm were not uncommon in patients with signet ring cell gastric tumours and lymph node metastases (six of 48; 13 per cent). CONCLUSION:Patients with early gastric cancer with signet ring cell-type histology are probably best treated by gastrectomy with lymph node dissection. Copyright 2010 British Journal of Surgery Society Ltd.
Authors: Hyeonjin Seong; Jin Il Kim; Hyun Jeong Lee; Hyun Jin Kim; Hyung Joon Cho; Hye Kang Kim; Dae Young Cheung; Dong Jin Kim; Wook Kim; Tae-Jung Kim Journal: World J Gastroenterol Date: 2013-11-28 Impact factor: 5.742
Authors: Chung Hyun Tae; Roos E Pouw; Lucas C Duits; Young Kyung Sung; Byung-Hoon Min; Jun Haeng Lee; Poong-Lyul Rhee; Kyoung-Mee Kim; Jacques J G H M Bergman; Jae J Kim Journal: Surg Endosc Date: 2014-10-08 Impact factor: 4.584