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Literature DB >> 20233133

Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study.

Xin-Ling Liang¹, Shuang-Xin Liu, Yuan-Han Chen, Li-Jun Yan, Heng Li, Hui-Jie Xuan, Yong-Zheng Liang, Wei Shi.

Abstract

The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20233133 DOI： 10.3109/13547501003706558

Source DB: PubMed Journal: Biomarkers ISSN： 1354-750X Impact factor: 2.658

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Cited

26 in total

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Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study.

Review 1. Klotho as a potential biomarker and therapy for acute kidney injury.

2. Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients.

3. Effects of General Anesthesia on 2 Urinary Biomarkers of Kidney Injury-Hepatitis A Virus Cellular Receptor 1 and Lipocalin 2-in Male C57BL/6J Mice.

4. Novel renal biomarker evaluation for early detection of acute kidney injury after transcatheter aortic valve implantation.

5. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function.

6. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.

7. Urinary kidney injury molecule-1 levels in renal stone patients.

Review 8. Biomarkers of acute kidney injury in neonatal encephalopathy.

9. Cardiorenal syndromes: pathophysiology to prevention.

10. Novel Biomarkers for Cardio-renal Syndrome.