| Literature DB >> 20232925 |
Valerie Lefebvre1, Thomas Cailly, Frederic Fabis, Sylvain Rault.
Abstract
A general two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles involving a palladium-catalyzed arylation of benzophenone hydrazone followed by an acidic deprotection/cyclization sequence is described. This procedure offers a general and efficient alternative to the typical S(N)Ar reaction of hydrazine with o-fluorobenzonitriles.Entities:
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Year: 2010 PMID： 20232925 DOI： 10.1021/jo100243c
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354