AIM: Describe lung tissue and central airway mechanics using forced oscillation in preterm rabbits at different gestational ages and after maternal administration of betamethasone (BM). METHODS: One hundred twelve fetuses from 54 does were studied. Ventilation was done using a Flexivent (Scireq, Montreal, Canada). Resistance (Rrs), compliance/bodyweight (Crs/bw), Newtonian resistance (Rn), tissue damping (G(L)), and elastance (H(L)) were assessed. Maturational changes were studied in normal controls at days 27-31. The effect of BM (0.05 mg/kg on days 25 and 26) or placebo was studied in preterm fetuses at days 27, 28, and 29. RESULTS: In unmanipulated control fetuses, Rrs decreased and Crs/bw increased with advancing gestation. Rn remained stable while G(L) and H(L) decreased. After day 29 no differences in pulmonary mechanics were observed. At 28 days Rrs and Crs/bw in BM and placebo fetuses were better compared to controls. At 29 days, Crs/bw and Rrs were higher, respectively, lower in control fetuses than BM or placebo exposed pups. CONCLUSION: Maturational changes in preterm rabbits occur mainly up to day 29 of gestation and are largely due to changes in tissue mechanics. Maternal BM injection improves lung mechanics at 28 days but placebo has equal effects.
AIM: Describe lung tissue and central airway mechanics using forced oscillation in preterm rabbits at different gestational ages and after maternal administration of betamethasone (BM). METHODS: One hundred twelve fetuses from 54 does were studied. Ventilation was done using a Flexivent (Scireq, Montreal, Canada). Resistance (Rrs), compliance/bodyweight (Crs/bw), Newtonian resistance (Rn), tissue damping (G(L)), and elastance (H(L)) were assessed. Maturational changes were studied in normal controls at days 27-31. The effect of BM (0.05 mg/kg on days 25 and 26) or placebo was studied in preterm fetuses at days 27, 28, and 29. RESULTS: In unmanipulated control fetuses, Rrs decreased and Crs/bw increased with advancing gestation. Rn remained stable while G(L) and H(L) decreased. After day 29 no differences in pulmonary mechanics were observed. At 28 days Rrs and Crs/bw in BM and placebo fetuses were better compared to controls. At 29 days, Crs/bw and Rrs were higher, respectively, lower in control fetuses than BM or placebo exposed pups. CONCLUSION: Maturational changes in preterm rabbits occur mainly up to day 29 of gestation and are largely due to changes in tissue mechanics. Maternal BM injection improves lung mechanics at 28 days but placebo has equal effects.
Authors: Kewal Asosingh; Georgiana Cheng; Weiling Xu; Benjamin M Savasky; Mark A Aronica; Xiaoxia Li; Serpil C Erzurum Journal: J Immunol Date: 2013-02-20 Impact factor: 5.422
Authors: Arnab Ghosh; Cynthia J Koziol-White; Kewal Asosingh; Georgina Cheng; Lisa Ruple; Dieter Groneberg; Andreas Friebe; Suzy A A Comhair; Johannes-Peter Stasch; Reynold A Panettieri; Mark A Aronica; Serpil C Erzurum; Dennis J Stuehr Journal: Proc Natl Acad Sci U S A Date: 2016-04-11 Impact factor: 11.205
Authors: Thomas Salaets; Margo Aertgeerts; André Gie; Janne Vignero; Derek de Winter; Yannick Regin; Julio Jimenez; Greetje Vande Velde; Karel Allegaert; Jan Deprest; Jaan Toelen Journal: Respir Res Date: 2020-02-21