OBJECTIVE: The purpose of this study was to evaluate whether MIB-1 labeling index (LI) could be used to predict growth velocity of residual pituitary adenomas after surgery. MATERIALS AND METHODS: One hundred and sixty pituitary adenomas which had not received other treatment modality except for surgery were collected. Each of them had at least two post-operative magnetic resonance imaging (MRI) studies with an interval of at least 1 month apart. Tumor volume doubling time (TVDT) was calculated for those in which volume increased. RESULTS: Post-operative tumor progression was noted in 54 (33.8%) cases, of which 39 (72.2%) cases were non-functioning adenomas. The MIB-1 LIs of the functioning and non-functioning adenomas were not significantly different. The median TVDT of these 54 cases was 34.6 months. The mean and median MIB-1 LI were 2.7 and 1.1 respectively (range 0.4-20.6). The MIB-1 LI was significantly correlated with log(2)(TVDT) (r=-0.363, P=0.007); when LI was <0.8, the TVDT of 90.5% cases was >or= 2 years. CONCLUSIONS: Only one-third of the pituitary adenomas progressed after surgery, and their MIB-1 LIs were generally low. The MIB-1 LI was significantly correlated with the MRI detected TVDT of post-operative residual pituitary adenomas.
OBJECTIVE: The purpose of this study was to evaluate whether MIB-1 labeling index (LI) could be used to predict growth velocity of residual pituitary adenomas after surgery. MATERIALS AND METHODS: One hundred and sixty pituitary adenomas which had not received other treatment modality except for surgery were collected. Each of them had at least two post-operative magnetic resonance imaging (MRI) studies with an interval of at least 1 month apart. Tumor volume doubling time (TVDT) was calculated for those in which volume increased. RESULTS: Post-operative tumor progression was noted in 54 (33.8%) cases, of which 39 (72.2%) cases were non-functioning adenomas. The MIB-1 LIs of the functioning and non-functioning adenomas were not significantly different. The median TVDT of these 54 cases was 34.6 months. The mean and median MIB-1 LI were 2.7 and 1.1 respectively (range 0.4-20.6). The MIB-1 LI was significantly correlated with log(2)(TVDT) (r=-0.363, P=0.007); when LI was <0.8, the TVDT of 90.5% cases was >or= 2 years. CONCLUSIONS: Only one-third of the pituitary adenomas progressed after surgery, and their MIB-1 LIs were generally low. The MIB-1 LI was significantly correlated with the MRI detected TVDT of post-operative residual pituitary adenomas.
Authors: Christian P Miermeister; Stephan Petersenn; Michael Buchfelder; Rudolf Fahlbusch; Dieter K Lüdecke; Annett Hölsken; Markus Bergmann; Hans Ulrich Knappe; Volkmar H Hans; Jörg Flitsch; Wolfgang Saeger; Rolf Buslei Journal: Acta Neuropathol Commun Date: 2015-08-19 Impact factor: 7.801
Authors: Alexander S G Micko; Adelheid Wöhrer; Romana Höftberger; Greisa Vila; Christine Marosi; Engelbert Knosp; Stefan Wolfsberger Journal: Pituitary Date: 2017-12 Impact factor: 4.107