OBJECTIVE: The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder. METHOD: Data were analyzed from 711 patients with bipolar I or II disorder who were followed prospectively over 7 years (13,191 visits). The main outcome measures were the presence of symptoms of depression or of hypomania or mania, measured by the Inventory of Depressive Symptomatology and the Young Mania Rating Scale. Data were analyzed using three separate repeated-measures regressions with a logistic link function to model the probability that an individual was depressed, manic, or euthymic. The models controlled for bipolar I or bipolar II diagnosis, rapid cycling, age, time in the study, comorbid anxiety disorders, and comorbid substance use disorders. RESULTS: In approximately half of visits, patients had depressive, manic, or hypomanic symptoms. The likelihood of having depressive symptoms was significantly greater for women than for men. This was accounted for by higher rates in women of rapid cycling and anxiety disorders, each of which was associated with increased rates of depression. All patient groups showed an increase in number of euthymic visits and a decrease in number of visits with depressive and manic symptoms with increased time in study. CONCLUSIONS: Bipolar patients spend a substantial proportion of their time ill. Significant gender differences exist, with women spending a greater proportion of their visits in the depressive pole. This finding appears to be related to the corresponding differences in rates of rapid cycling and anxiety disorders.
OBJECTIVE: The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder. METHOD: Data were analyzed from 711 patients with bipolar I or II disorder who were followed prospectively over 7 years (13,191 visits). The main outcome measures were the presence of symptoms of depression or of hypomania or mania, measured by the Inventory of Depressive Symptomatology and the Young Mania Rating Scale. Data were analyzed using three separate repeated-measures regressions with a logistic link function to model the probability that an individual was depressed, manic, or euthymic. The models controlled for bipolar I or bipolar II diagnosis, rapid cycling, age, time in the study, comorbid anxiety disorders, and comorbid substance use disorders. RESULTS: In approximately half of visits, patients had depressive, manic, or hypomanic symptoms. The likelihood of having depressive symptoms was significantly greater for women than for men. This was accounted for by higher rates in women of rapid cycling and anxiety disorders, each of which was associated with increased rates of depression. All patient groups showed an increase in number of euthymic visits and a decrease in number of visits with depressive and manic symptoms with increased time in study. CONCLUSIONS: Bipolar patients spend a substantial proportion of their time ill. Significant gender differences exist, with women spending a greater proportion of their visits in the depressive pole. This finding appears to be related to the corresponding differences in rates of rapid cycling and anxiety disorders.
Authors: Wendy K Marsh; Terence A Ketter; Sybil L Crawford; Julia V Johnson; Aimee R Kroll-Desrosiers; Anthony J Rothschild Journal: Bipolar Disord Date: 2012-05-31 Impact factor: 6.744
Authors: Elena Aragno; Andrea Fagiolini; Alessandro Cuomo; Elena Paschetta; Giuseppe Maina; Gianluca Rosso Journal: Arch Womens Ment Health Date: 2022-03-02 Impact factor: 3.633
Authors: Maria Syl D de la Cruz; Zongshan Lai; David E Goodrich; Amy M Kilbourne Journal: Arch Womens Ment Health Date: 2013-04-16 Impact factor: 3.633
Authors: A K Leonpacher; D Liebers; M Pirooznia; D Jancic; D F MacKinnon; F M Mondimore; B Schweizer; J B Potash; P P Zandi; F S Goes Journal: Psychol Med Date: 2015-04-08 Impact factor: 7.723