| Literature DB >> 20231027 |
Chengli Shen1, Ming Ding, Jodi K Craigo, Patrick Tarwater, Ramdas Chatterjee, Pratima Roy, Subhasish K Guha, Bibhuti Saha, Dolonchapa Modak, Dhrubak Neogi, Yue Chen, Phalguni Gupta.
Abstract
Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects. 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20231027 PMCID： PMC2872239 DOI： 10.1016/j.virol.2010.01.033
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616