| Literature DB >> 20230918 |
Young Min Son1, Chae Won Kwak, Yeo Jin Lee, Deok-Chun Yang, Byung-Chul Park, Woon Kyu Lee, Seung Hyun Han, Cheol-Heui Yun.
Abstract
In the present study, we examined the effects of ginsenoside Re (Re) on cytokine expression, cytokine-dependent autophagy and cell survival in human CD4(+) T cells. When CD4(+) T cells isolated from human peripheral blood were treated with Re, LC3 and monodansylcadaverine (MDC), representative markers of autophagy, were decreased in a dose-dependent manner. Interestingly, Re suppressed the production of interferon-gamma (IFN-gamma) and immunity-related GTPase family M (IRGM) in CD4(+) T cells whereas no changes in other autophagy-related signaling molecules (ERK, p38 and AKT-mTOR-p70S6k) were found. Concomitantly, we observed that Re increased the proliferation of CD4(+) T cells with decreased cell death. Our results demonstrate that ginsenoside Re enhanced viability of CD4(+) T cells through the regulation of IFN-gamma-dependent autophagy activity. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20230918 DOI： 10.1016/j.intimp.2010.03.002
Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932