BACKGROUND: Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell transplant, is generally regarded to develop through cell-mediated immune response following activation of helper T cells. Since production of antibodies is also mediated by helper T cells, the role of humoral immunity in GVHD is questioned and has not yet been explored in clinical practice. We conducted a pilot study to evaluate the role of antibody production in hepatic H-GVHD and whether it can distinguish acute and chronic forms. RESULTS: C4d expression was increased in portal vessels and hepatic sinusoids of patients with histological proven evidence of GVHD 11/16 (P=0.007). Patients classified as chronic GVHD were statistically more likely to have C4d expression in the portal vasculature and liver sinusoids (P=0.011). CONCLUSION: Humoral activation seems to play a role in pathophysiology of hepatic, especially chronic GVHD. Copyright (c) 2010 Elsevier B.V. All rights reserved.
BACKGROUND:Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell transplant, is generally regarded to develop through cell-mediated immune response following activation of helper T cells. Since production of antibodies is also mediated by helper T cells, the role of humoral immunity in GVHD is questioned and has not yet been explored in clinical practice. We conducted a pilot study to evaluate the role of antibody production in hepatic H-GVHD and whether it can distinguish acute and chronic forms. RESULTS: C4d expression was increased in portal vessels and hepatic sinusoids of patients with histological proven evidence of GVHD 11/16 (P=0.007). Patients classified as chronic GVHD were statistically more likely to have C4d expression in the portal vasculature and liver sinusoids (P=0.011). CONCLUSION: Humoral activation seems to play a role in pathophysiology of hepatic, especially chronic GVHD. Copyright (c) 2010 Elsevier B.V. All rights reserved.
Authors: Howard M Shulman; Diana M Cardona; Joel K Greenson; Sangeeta Hingorani; Thomas Horn; Elisabeth Huber; Andreas Kreft; Thomas Longerich; Thomas Morton; David Myerson; Victor G Prieto; Avi Rosenberg; Nathaniel Treister; Kay Washington; Mirjana Ziemer; Steven Z Pavletic; Stephanie J Lee; Mary E D Flowers; Kirk R Schultz; Madan Jagasia; Paul J Martin; Georgia B Vogelsang; David E Kleiner Journal: Biol Blood Marrow Transplant Date: 2015-01-29 Impact factor: 5.742
Authors: Judith Stift; Hideo A Baba; Elisabeth Huber; Birgit Federmann; Hans-Peter Fischer; Annette Schmitt-Graeff; Herrad Baurmann; Wolfgang Bethge; Peter Schirmacher; Fritz Wrba; Hildegard Greinix; Falko Fend; Rainer Schwerdtfeger; Howard M Shulman; Daniel Wolff; Thomas Longerich Journal: Virchows Arch Date: 2014-01-03 Impact factor: 4.535