AIMS: This study was conducted to investigate the associations between single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) and Kawasaki disease (KD) in the Korean population. MAIN METHODS: A total 0f 101 KD patients and 306 healthy controls were examined. MMP7 (rs10502001, G/A, Arg77His), MMP11 (rs738792, T/C, Ala38Val), MMP12 (rs652438, A/G, Ile357Val) and MMP26 (rs2499953, A/G, Lys43Glu) genes were genotyped from the genomic DNA using direct sequencing. The results were then analyzed using logistic regression models, adjusting for gender as covariates. KEY FINDINGS: The four SNPs were in Hardy-Weinberg equilibrium. Only the MMP11 polymorphism (rs738792) was associated with KD. The SNP (rs738792) showed a statistically significant association with KD in the codominant (OR=1.61, 95% CI=1.11-2.34, P=0.011) and dominant (OR=1.92, 95% CI=1.21-3.06, P=0.006) models. However, there was no association between polymorphisms of other MMP genes and KD. SIGNIFICANCE: Overall, the results of this study indicate that MMP11 polymorphism may be associated with KD in the Korean population. Copyright 2010 Elsevier Inc. All rights reserved.
AIMS: This study was conducted to investigate the associations between single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) and Kawasaki disease (KD) in the Korean population. MAIN METHODS: A total 0f 101 KDpatients and 306 healthy controls were examined. MMP7 (rs10502001, G/A, Arg77His), MMP11 (rs738792, T/C, Ala38Val), MMP12 (rs652438, A/G, Ile357Val) and MMP26 (rs2499953, A/G, Lys43Glu) genes were genotyped from the genomic DNA using direct sequencing. The results were then analyzed using logistic regression models, adjusting for gender as covariates. KEY FINDINGS: The four SNPs were in Hardy-Weinberg equilibrium. Only the MMP11 polymorphism (rs738792) was associated with KD. The SNP (rs738792) showed a statistically significant association with KD in the codominant (OR=1.61, 95% CI=1.11-2.34, P=0.011) and dominant (OR=1.92, 95% CI=1.21-3.06, P=0.006) models. However, there was no association between polymorphisms of other MMP genes and KD. SIGNIFICANCE: Overall, the results of this study indicate that MMP11 polymorphism may be associated with KD in the Korean population. Copyright 2010 Elsevier Inc. All rights reserved.