BACKGROUND: Emerging evidence suggests that there is a significant genetic component to human longevity. One or more genetic variants located on chromosome 9p21.3 and tagged by the single-nucleotide polymorphism (SNP) rs1333049 (G/C) are major risk factors for age-related disorders, including acute myocardial infarction (AMI), stroke, and dementia. We hypothesized that this locus may have widespread effects on aging phenotypes and, as such, influences the ability to achieve a long and healthy life. AIM: The aim of this study was to assess whether the rs1333049 polymorphism is associated with human longevity. METHODS: We tested the rs1333049 polymorphism in a sample of 80 healthy centenarians (39 men and 41 women, aged 100-104), 218 patients younger than 40 who experienced an AMI, and a control group of 258 healthy young volunteers matched to AMI patients for age and sex. RESULTS: The frequency of the C allele of rs1333049 was significantly lower in centenarians compared to young controls, whereas AMI patients showed a higher frequency. After adjustment for gender and traditional vascular risk factors, the C allele of rs1333049 remained significantly associated with a reduced likelihood to reach longevity: Odds ratio (OR) 0.64, 95% confidence interval (CI) 0.39-0.89, p < 0.01. CONCLUSIONS: Our data suggest that the rs1333049 polymorphism at 9p21.3 may influence successful human longevity, possibly by modulating the risk of age-related disorders.
BACKGROUND: Emerging evidence suggests that there is a significant genetic component to human longevity. One or more genetic variants located on chromosome 9p21.3 and tagged by the single-nucleotide polymorphism (SNP) rs1333049 (G/C) are major risk factors for age-related disorders, including acute myocardial infarction (AMI), stroke, and dementia. We hypothesized that this locus may have widespread effects on aging phenotypes and, as such, influences the ability to achieve a long and healthy life. AIM: The aim of this study was to assess whether the rs1333049 polymorphism is associated with human longevity. METHODS: We tested the rs1333049 polymorphism in a sample of 80 healthy centenarians (39 men and 41 women, aged 100-104), 218 patients younger than 40 who experienced an AMI, and a control group of 258 healthy young volunteers matched to AMI patients for age and sex. RESULTS: The frequency of the C allele of rs1333049 was significantly lower in centenarians compared to young controls, whereas AMI patients showed a higher frequency. After adjustment for gender and traditional vascular risk factors, the C allele of rs1333049 remained significantly associated with a reduced likelihood to reach longevity: Odds ratio (OR) 0.64, 95% confidence interval (CI) 0.39-0.89, p < 0.01. CONCLUSIONS: Our data suggest that the rs1333049 polymorphism at 9p21.3 may influence successful human longevity, possibly by modulating the risk of age-related disorders.
Authors: Robert W Davies; Sonny Dandona; Alexandre F R Stewart; Li Chen; Stephan G Ellis; W H Wilson Tang; Stanley L Hazen; Robert Roberts; Ruth McPherson; George A Wells Journal: Circ Cardiovasc Genet Date: 2010-08-21
Authors: Yan Liu; Soren M Johnson; Yuri Fedoriw; Arlin B Rogers; Hong Yuan; Janakiraman Krishnamurthy; Norman E Sharpless Journal: Blood Date: 2011-01-18 Impact factor: 22.113
Authors: Jonatan R Ruiz; Carmen Fiuza-Luces; Amaya Buxens; Amalia Cano-Nieto; Félix Gómez-Gallego; Catalina Santiago; Gabriel Rodríguez-Romo; Nuria Garatachea; José I Lao; María Morán; Alejandro Lucia Journal: Age (Dordr) Date: 2011-09-06
Authors: Christin E Burd; William R Jeck; Yan Liu; Hanna K Sanoff; Zefeng Wang; Norman E Sharpless Journal: PLoS Genet Date: 2010-12-02 Impact factor: 5.917
Authors: Nuria Garatachea; Tomàs Pinós; Yolanda Cámara; Gabriel Rodríguez-Romo; Enzo Emanuele; Giovanni Ricevuti; Letizia Venturini; Alejandro Santos-Lozano; Catalina Santiago-Dorrego; Carmen Fiuza-Luces; Thomas Yvert; Antoni L Andreu; Alejandro Lucia Journal: Age (Dordr) Date: 2013-01-25
Authors: Ambarish Dutta; William Henley; Iain A Lang; Anna Murray; Jack Guralnik; Robert B Wallace; David Melzer Journal: Circ Cardiovasc Genet Date: 2011-08-18