Literature DB >> 20228869

Synthesis of Tritium Labeled (R,R)-4-Methoxyfenoterol.

Joseph A Kozocas1, James E Bupp, Mary J Tanga, Joseph T Pluhar, Irving W Wainer.   

Abstract

The preparation of 2',4',6'-[(3)H(3)]-(R,R)-4-methoxyfenoterol, a tritium-labeled derivative of (R,R)-4-methoxyfenoterol was demonstrated on a 15 mCi scale providing material with a specific activity of 57 Ci/mmol.

Entities:  

Year:  2010        PMID： 20228869      PMCID： PMC2835161          DOI： 10.1002/jlcr.1703

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  2 in total

1.  Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes.

Authors:  Anthony Yiu-Ho Woo; Tian-Bing Wang; Xiaokun Zeng; Weizhong Zhu; Darrell R Abernethy; Irving W Wainer; Rui-Ping Xiao
Journal:  Mol Pharmacol       Date:  2008-10-07       Impact factor: 4.436

2.  Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

Authors:  Krzysztof Jozwiak; Chakir Khalid; Mary J Tanga; Ilona Berzetei-Gurske; Lucita Jimenez; Joseph A Kozocas; Anthony Woo; Weizhong Zhu; Rui-Ping Xiao; Darrell R Abernethy; Irving W Wainer
Journal:  J Med Chem       Date:  2007-05-17       Impact factor: 7.446
  2 in total
  4 in total

1.  Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding.

Authors:  Michael T Reinartz; Solveig Kälble; Irving W Wainer; Roland Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-01-31       Impact factor: 3.000

2.  The stereoselective sulfate conjugation of 4'-methoxyfenoterol stereoisomers by sulfotransferase enzymes.

Authors:  Lalitha V Iyer; Anuradha Ramamoorthy; Ewelina Rutkowska; Anna M Furimsky; Liang Tang; Paul Catz; Carol E Green; Krzysztof Jozwiak; Irving W Wainer
Journal:  Chirality       Date:  2012-06-29       Impact factor: 2.437

3.  Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.

Authors:  Lawrence Toll; Karolina Pajak; Anita Plazinska; Krzysztof Jozwiak; Lucita Jimenez; Joseph A Kozocas; Mary J Tanga; James E Bupp; Irving W Wainer
Journal:  Mol Pharmacol       Date:  2012-03-20       Impact factor: 4.436

4.  The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor.

Authors:  Krzysztof Jozwiak; Lawrence Toll; Lucita Jimenez; Anthony Yiu-Ho Woo; Rui-Ping Xiao; Irving W Wainer
Journal:  Biochem Pharmacol       Date:  2010-02-06       Impact factor: 5.858
  4 in total

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