CONTEXT: Chemotherapy-induced nausea and vomiting (CINV) is a significant problem in the treatment of children with cancer. The last decade has seen a variety of newer antiemetics being evaluated for CINV; their efficacy and side effects need to be assessed in children. This article attempts to highlight this revised management of CINV. EVIDENCE ACQUISITION: Online search; journals. Search period: 6 months. RESULTS: Newer drugs (aprepitant, fosapritant and newer 5HT3 antagonists) have been found to be effective in CINV: both acute and delayed phases. Most of the available literature is, however, based on adult oncology patients, with a few trials on adolescent patients. CONCLUSION: Every child receiving treatment for cancer should be evaluated for possible CINV. Their treatment should take into account the emetogenic potential of the chemotherapeutic drugs. Newer antiemetic drugs have good efficacy and can be tried in pediatric patients, especially in children > 11 years of age.
CONTEXT: Chemotherapy-induced nausea and vomiting (CINV) is a significant problem in the treatment of children with cancer. The last decade has seen a variety of newer antiemetics being evaluated for CINV; their efficacy and side effects need to be assessed in children. This article attempts to highlight this revised management of CINV. EVIDENCE ACQUISITION: Online search; journals. Search period: 6 months. RESULTS: Newer drugs (aprepitant, fosapritant and newer 5HT3 antagonists) have been found to be effective in CINV: both acute and delayed phases. Most of the available literature is, however, based on adult oncology patients, with a few trials on adolescent patients. CONCLUSION: Every child receiving treatment for cancer should be evaluated for possible CINV. Their treatment should take into account the emetogenic potential of the chemotherapeutic drugs. Newer antiemetic drugs have good efficacy and can be tried in pediatric patients, especially in children > 11 years of age.
Authors: Sunita Vohra; Michael Schlegelmilch; Hsing Jou; Dawn Hartfield; Maria Mayan; Arto Ohinmaa; Bev Wilson; Maria Spavor; Paul Grundy Journal: Contemp Clin Trials Commun Date: 2016-11-23