Literature DB >> 20227773

Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity.

Harleen Saini1, Gregory Fernandez, Douglas Kerr, Michael Levy.   

Abstract

Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG biomarker. AQP4 is expressed as two isoforms: M1 and M23, which have different functions in the central nervous system (CNS). We characterized the expression pattern of these AQP4 isoform mRNAs in humans and found a pattern of AQP4 expression that correlates with NMO disease localization. The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices. Copyright 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20227773     DOI： 10.1016/j.jneuroim.2010.02.007

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  11 in total

1.  Optic neuritis in neuromyelitis optica.

Authors:  Marc H Levin; Jeffrey L Bennett; A S Verkman
Journal:  Prog Retin Eye Res       Date:  2013-03-30       Impact factor: 21.198

2.  The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness.

Authors:  Jihong Tong; Zhe Wu; Margaret M Briggs; Klaus Schulten; Thomas J McIntosh
Journal:  Biophys J       Date:  2016-07-12       Impact factor: 4.033

3.  Anti-aquaporin-4 antibodies in Devic's neuromyelitis optica: therapeutic implications.

Authors:  Romain Marignier; Pascale Giraudon; Sandra Vukusic; Christian Confavreux; Jérôme Honnorat
Journal:  Ther Adv Neurol Disord       Date:  2010-09       Impact factor: 6.570

4.  Sera of Neuromyelitis Optica Patients Increase BID-Mediated Apoptosis in Astrocytes.

Authors:  Omri Zveik; Ariel Rechtman; Nitzan Haham; Irit Adini; Tamar Canello; Iris Lavon; Livnat Brill; Adi Vaknin-Dembinsky
Journal:  Int J Mol Sci       Date:  2022-06-27       Impact factor: 6.208

5.  Review of Animal Models of Neuromyelitis Optica.

Authors:  Melina V Jones; Nicolas Collongues; Jerome de Seze; Makoto Kinoshita; Yuji Nakatsuji; Michael Levy
Journal:  Mult Scler Relat Disord       Date:  2012-10       Impact factor: 4.339

Review 6.  Immunology of neuromyelitis optica: a T cell-B cell collaboration.

Authors:  Meike Mitsdoerffer; Vijay Kuchroo; Thomas Korn
Journal:  Ann N Y Acad Sci       Date:  2013-04       Impact factor: 5.691

7.  Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity.

Authors:  Jihong Tong; Margaret M Briggs; Thomas J McIntosh
Journal:  Biophys J       Date:  2012-11-07       Impact factor: 4.033

8.  Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica.

Authors:  Sudhakar Reddy Kalluri; Veit Rothhammer; Ori Staszewski; Rajneesh Srivastava; Franziska Petermann; Marco Prinz; Bernhard Hemmer; Thomas Korn
Journal:  PLoS One       Date:  2011-01-14       Impact factor: 3.240

9.  Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G.

Authors:  Xiaoming Yao; Alan S Verkman
Journal:  Acta Neuropathol Commun       Date:  2017-07-27       Impact factor: 7.801

10.  GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica.

Authors:  Fumitaka Shimizu; Yukio Takeshita; Yuka Hamamoto; Hideaki Nishihara; Yasuteru Sano; Masaya Honda; Ryota Sato; Toshihiko Maeda; Toshiyuki Takahashi; Susumu Fujikawa; Takashi Kanda
Journal:  Ann Clin Transl Neurol       Date:  2019-09-30       Impact factor: 4.511
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