Literature DB >> 20227031

Adverse effects of drugs in the treatment of viral hepatitis.

Francesco Negro1.   

Abstract

The hepatitis B virus (HBV) and the hepatitis C virus (HCV) affect approximately 400-500 million individuals worldwide. Both infections are characterised by a significant morbidity and mortality: chronic hepatitis B and C may evolve towards the development of cirrhosis and primary hepatocellular carcinoma. During the last two decades, several new antivirals have been developed that are active against HBV and HCV, allowing sustained cure rates in a significant proportion of patients. All these drugs have side effects, which may represent a major barrier to achieve cure in many patients in need. I will review the most common adverse events reported during the therapy of chronic hepatitis B and C, with some recommendations for proper management. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20227031     DOI: 10.1016/j.bpg.2009.10.012

Source DB:  PubMed          Journal:  Best Pract Res Clin Gastroenterol        ISSN: 1521-6918            Impact factor:   3.043


  20 in total

1.  Commentary: sofosbuvir for treatment of hepatitis C virus genotype 2 or 3 infection in patients without treatment options.

Authors:  Steven L Flamm
Journal:  Gastroenterol Hepatol (N Y)       Date:  2013-10

2.  Boceprevir for previously treated chronic HCV genotype 1 infection.

Authors:  Bruce R Bacon; Stuart C Gordon; Eric Lawitz; Patrick Marcellin; John M Vierling; Stefan Zeuzem; Fred Poordad; Zachary D Goodman; Heather L Sings; Navdeep Boparai; Margaret Burroughs; Clifford A Brass; Janice K Albrecht; Rafael Esteban
Journal:  N Engl J Med       Date:  2011-03-31       Impact factor: 91.245

3.  Inhibition of HBV replication by VPS4B and its dominant negative mutant VPS4B-K180Q in vivo.

Authors:  Jianbo Xia; Weipeng Wang; Lei Li; Zhi Liu; Min Liu; Dongliang Yang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-06-09

Review 4.  Environmental triggers of thyroiditis: hepatitis C and interferon-α.

Authors:  F Menconi; A Hasham; Y Tomer
Journal:  J Endocrinol Invest       Date:  2010-02-28       Impact factor: 4.256

5.  Biodegradable nanogels for oral delivery of interferon for norovirus infection.

Authors:  Yunjeong Kim; Mahendra Thapa; Duy H Hua; Kyeong-Ok Chang
Journal:  Antiviral Res       Date:  2010-12-07       Impact factor: 5.970

Review 6.  New treatments for chronic hepatitis C: an overview for paediatricians.

Authors:  Daniele Serranti; Giuseppe Indolfi; Massimo Resti
Journal:  World J Gastroenterol       Date:  2014-11-21       Impact factor: 5.742

Review 7.  Hepatitis C virus infection: Are there still specific problems with genotype 3?

Authors:  Claire Gondeau; Georges Philippe Pageaux; Dominique Larrey
Journal:  World J Gastroenterol       Date:  2015-11-14       Impact factor: 5.742

8.  Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects.

Authors:  Jill Denning; Melanie Cornpropst; Stephen D Flach; Michelle M Berrey; William T Symonds
Journal:  Antimicrob Agents Chemother       Date:  2012-12-21       Impact factor: 5.191

9.  Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication.

Authors:  Jacques Friborg; Steven Levine; Chaoqun Chen; Amy K Sheaffer; Susan Chaniewski; Stacey Voss; Julie A Lemm; Fiona McPhee
Journal:  Antimicrob Agents Chemother       Date:  2012-12-28       Impact factor: 5.191

10.  Acute inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alfa-2a in a patient with chronic hepatitis C virus infection: a case report.

Authors:  Mounia Lahbabi; Meryem Ghissassi; Faouzi Belahcen; Sidi Adil Ibrahimi; Nouredine Aqodad
Journal:  J Med Case Rep       Date:  2012-09-04
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