| Literature DB >> 2022699 |
K Tashiro1, G C Sephel, D Greatorex, M Sasaki, N Shirashi, G R Martin, H K Kleinman, Y Yamada.
Abstract
The laminin A chain has been sequenced by cDNA cloning and was found to contain an RGD sequence. Synthetic peptides containing the RGD sequence and flanking amino acids were active in mediating cell adhesion, spreading, migration, and neurite outgrowth. Furthermore, endothelial cell attachment to a laminin substrate was inhibited by an RGD-containing synthetic peptide. Antisera against the integrin (fibronectin) receptor, and monoclonal antibody to the integrin, VLA-6, inhibited cell interaction with laminin, as well as with peptides containing an RGD sequence. These results suggest that the RGD containing site of laminin is active and interacts with the integrin family of receptors in certain cells.Entities:
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Year: 1991 PMID： 2022699 DOI： 10.1002/jcp.1041460316
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384