Literature DB >> 202267

Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.

A M Malkinson, T J Gunderson, C E McSwigan.   

Abstract

The cyclic AMP-dependent protein kinase specific activities of cytosol fractions from urethane-induced lung tumours and from normal mouse lung were determined. Both basal and cyclic AMP-stimulated activities in tumours were twofold higher than those of normal lung. Since neonatal and adult lung cytosols have identical kinase activities, the high activity in tumours appears to be a tumour-specific property.

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Year:  1977        PMID： 202267      PMCID： PMC1183768          DOI： 10.1042/bj1680319

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

Review 1.  Lung tumors in mice: application to carcinogenesis bioassay.

Authors:  M B Shimkin; G D Stoner
Journal:  Adv Cancer Res       Date:  1975       Impact factor: 6.242

2.  Cyclic AMP-dependent protein kinases from normal and SV40-transformed 3T3 cells.

Authors:  A J Gharrett; A M Malkinson; J R Sheppard
Journal:  Nature       Date:  1976-12-16       Impact factor: 49.962

Review 3.  Role of cyclic nucleotides in cancer.

Authors:  W L Ryan; M L Heidrick
Journal:  Adv Cyclic Nucleotide Res       Date:  1974

4.  Protein kinase activity in Morris hepatomas.

Authors:  W E Criss; H P Morris
Journal:  Biochem Biophys Res Commun       Date:  1973-09-05       Impact factor: 3.575

5.  Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.

Authors:  J Otten; G S Johnson; I Pastan
Journal:  Biochem Biophys Res Commun       Date:  1971-09       Impact factor: 3.575

6.  Cyclic-3', 5'-AMP-dependent and independent protein kinase levels in normal and feline sarcoma virus transformed cells.

Authors:  F A Troy; I K Vijay; T G Kawakami
Journal:  Biochem Biophys Res Commun       Date:  1973-05-01       Impact factor: 3.575

7.  Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue.

Authors:  J D Corbin; P H Sugden; T M Lincoln; S L Keely
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

8.  Characterization and regulation of heart adenosine 3':5'-monophosphate-dependent protein kinase isozymes.

Authors:  J D Corbin; S L Keely
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

9.  Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives.

Authors:  G S Johnson; R M Friedman; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

10.  Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate.

Authors:  J R Sheppard
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205
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