| Literature DB >> 20225835 |
Kyosuke Tanaka1, Masahito Watanabe, Kodai Ishibashi, Hiroshi Matsuyama, Yoko Saikawa, Masaya Nakata.
Abstract
One-step formation of the ansa-skeleton realized the synthesis of kendomycin, an ansa-type quinone methide. The Fischer carbene complex derived from the ansa-chain portion was subjected to the intramolecular Dotz benzannulation to afford the desired oxametacyclophane with exclusive regioselectivity. Subsequent Claisen rearrangement, ortho oxidation of the resulting phenol derivative, and mild transformation from p-quinone to p-quinone methide on a silica gel plate furnished kendomycin.Entities:
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Year: 2010 PMID： 20225835 DOI： 10.1021/ol100229f
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005