| Literature DB >> 20225292 |
Ingrid A F van der Mei1, Arine-Louise Ponsonby, Bruce V Taylor, Jim Stankovich, Joanne L Dickinson, Simon Foote, Andrew Kemp, Terence Dwyer.
Abstract
The risk for development of multiple sclerosis has been associated with human leukocyte antigen-DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein-Barr nuclear antigen IgG levels. In a population-based case-control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43-18.11) was 3.9-fold greater than expected (test for interaction, p = 0.019) This interaction was observed irrespective of Epstein-Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life. Ann Neurol 2009;66:261-265 ANN NEUROL 2010;67:259-263.Entities:
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Year: 2010 PMID： 20225292 DOI： 10.1002/ana.21849
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422