| Literature DB >> 20225020 |
Antonella Spinazzola1, Massimo Zeviani.
Abstract
More than one billion years ago, mitochondria were free-living prokaryotic organisms with their own DNA. However, during the evolution, ancestral genes have been transferred from the mitochondrial to the nuclear genome so that mtDNA became dependent on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause Mendelian diseases that affect mtDNA integrity or expression.Entities:
Mesh：
Year: 2009 PMID： 20225020 DOI： 10.1007/978-90-481-2813-6_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622