Literature DB >> 20225001

Attention deficit hyperactivity disorder: diagnosis and treatment masking the ophthalmic clinical presentation of a pineal gland tumour in a teenager.

G Cunniffe1, R Murthy, B Beigi.   

Abstract

A 17-year-old male was found to have a fourth cranial nerve palsy and chronic papilloedema following his presentation to our institution with a 6-week history of blurred vision in both eyes and vertical binocular diplopia. A diagnosis of pineal germinoma was made following imaging studies and endoscopic neurosurgical biopsy of the tumour. He was diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) 3 years earlier and treated with amphetamines. Since this diagnosis, he continued to suffer from hyperactive behaviour, poor concentration, worsening headaches and insomnia. Pineal pathology has a known association with sleep disturbance through the disturbance of melatonin synthesis and/or metabolism. This case report serves to highlight how the presence of organic brain disease presenting to an eye department can be masked by a diagnosis of ADHD.

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Year:  2010        PMID: 20225001     DOI: 10.1007/s10792-010-9356-1

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  19 in total

1.  Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation.

Authors:  R A Barkley; M B McMurray; C S Edelbrock; K Robbins
Journal:  Pediatrics       Date:  1990-08       Impact factor: 7.124

2.  The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder.

Authors:  Russell A Barkley; Mariellen Fischer; Lori Smallish; Kenneth Fletcher
Journal:  J Abnorm Psychol       Date:  2002-05

3.  Tumors of the pineal and suprasellar region: Childrens Cancer Study Group treatment results 1960--1975: a report from Childrens Cancer Study Group.

Authors:  W M Wara; R D Jenkin; A Evans; I Ertel; R Hittle; J Ortega; C B Wilson; D Hammond
Journal:  Cancer       Date:  1979-02       Impact factor: 6.860

4.  Suprasellar germinoma: radiation therapy.

Authors:  J N Fields; K H Fulling; P R Thomas; J E Marks
Journal:  Radiology       Date:  1987-07       Impact factor: 11.105

5.  Immunohistochemical study of placental alkaline phosphatase in primary intracranial germ-cell tumors.

Authors:  J Shinoda; Y Miwa; N Sakai; H Yamada; H Shima; K Kato; M Takahashi; K Shimokawa
Journal:  J Neurosurg       Date:  1985-11       Impact factor: 5.115

Review 6.  Pineal tumors.

Authors:  J E Baumgartner; M S Edwards
Journal:  Neurosurg Clin N Am       Date:  1992-10       Impact factor: 2.509

7.  Endocrine disturbances in suprasellar germinomas.

Authors:  M Buchfelder; R Fahlbusch; M Walther; K Mann
Journal:  Acta Endocrinol (Copenh)       Date:  1989-03

8.  Melatonin replacement corrects sleep disturbances in a child with pineal tumor.

Authors:  A Etzioni; R Luboshitzky; D Tiosano; M Ben-Harush; D Goldsher; P Lavie
Journal:  Neurology       Date:  1996-01       Impact factor: 9.910

9.  Treatment results of intracranial germinoma as a function of the irradiated volume.

Authors:  Y Shibamoto; M Abe; J Yamashita; M Takahashi; M Hiraoka; K Ono; K Tsutsui
Journal:  Int J Radiat Oncol Biol Phys       Date:  1988-08       Impact factor: 7.038

Review 10.  Intracranial germ-cell tumors: natural history and pathogenesis.

Authors:  M T Jennings; R Gelman; F Hochberg
Journal:  J Neurosurg       Date:  1985-08       Impact factor: 5.115

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