PURPOSE OF REVIEW: Primary biliary cirrhosis (PBC) is a human autoimmune liver disease whose molecular pathogenesis is poorly understood because of the difficulty in accessing human tissue and the absence of appropriate animal models. Recently, several unique murine models of human PBC have been discovered. These models have great potential for illustrating the cause and the cellular events that lead to biliary-specific damage. The purpose of this review is to summarize recent progress in these models. RECENT FINDINGS: The murine models of autoimmune cholangitis include the transforming growth factor beta receptor II (TGF-betaRII) dominant-negative (dnTGF-betaRII), IL-2 receptor alpha deleted (IL-2Ralpha-/-), scurfy, nonobese diabetic (NOD) c3c4, and Ae2 gene-disrupted (Ae2a,b-/-) mice. Recently, we have also established a successful murine model following the immunization with a chemical mimicry of the lipoyl-lysine residue of the E2 component of PDC-E2. SUMMARY: These emerging murine models have greatly enabled researchers to address the pathogenesis of human PBC and to elucidate pathogenic factors. These models will ultimately lead to new therapeutic options for human PBC.
PURPOSE OF REVIEW: Primary biliary cirrhosis (PBC) is a humanautoimmune liver disease whose molecular pathogenesis is poorly understood because of the difficulty in accessing human tissue and the absence of appropriate animal models. Recently, several unique murine models of human PBC have been discovered. These models have great potential for illustrating the cause and the cellular events that lead to biliary-specific damage. The purpose of this review is to summarize recent progress in these models. RECENT FINDINGS: The murine models of autoimmune cholangitis include the transforming growth factor beta receptor II (TGF-betaRII) dominant-negative (dnTGF-betaRII), IL-2 receptor alpha deleted (IL-2Ralpha-/-), scurfy, nonobese diabetic (NOD) c3c4, and Ae2 gene-disrupted (Ae2a,b-/-) mice. Recently, we have also established a successful murine model following the immunization with a chemical mimicry of the lipoyl-lysine residue of the E2 component of PDC-E2. SUMMARY: These emerging murine models have greatly enabled researchers to address the pathogenesis of human PBC and to elucidate pathogenic factors. These models will ultimately lead to new therapeutic options for human PBC.
Authors: Masanobu Tsuda; Yoko M Ambrosini; Weici Zhang; Guo-Xiang Yang; Yugo Ando; Guanghua Rong; Koichi Tsuneyama; Kosuke Sumida; Shinji Shimoda; Christopher L Bowlus; Patrick S C Leung; Xiao-Song He; Ross L Coppel; Aftab A Ansari; Zhe-Xiong Lian; M Eric Gershwin Journal: Hepatology Date: 2011-10 Impact factor: 17.425
Authors: Yuki Moritoki; Masanobu Tsuda; Koichi Tsuneyama; Weici Zhang; Katsunori Yoshida; Zhe-Xiong Lian; Guo-Xiang Yang; William M Ridgway; Linda S Wicker; Aftab A Ansari; M Eric Gershwin Journal: Cell Immunol Date: 2011-01-28 Impact factor: 4.868
Authors: Y M Ambrosini; G-X Yang; W Zhang; M Tsuda; S Shu; K Tsuneyama; P S C Leung; A A Ansari; R L Coppel; M E Gershwin Journal: Clin Exp Immunol Date: 2011-10 Impact factor: 4.330
Authors: C-Y Yang; P S C Leung; G-X Yang; T P Kenny; W Zhang; R Coppel; G L Norman; A A Ansari; I R Mackay; H J Worman; M E Gershwin Journal: Clin Exp Immunol Date: 2012-06 Impact factor: 4.330