Mariska van Vliet1, Josine C Van der Heyden2, Michaela Diamant3, Inès A Von Rosenstiel4, Roger K Schindhelm5, Henk J Aanstoot6, Henk J Veeze6. 1. Department of Pediatrics, Slotervaart Hospital, Amsterdam, The Netherlands; Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. 2. Diabeter, Rotterdam, The Netherlands. Electronic address: J.vanderHeyden@diabeter.nl. 3. Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. 4. Department of Pediatrics, Slotervaart Hospital, Amsterdam, The Netherlands. 5. Department of Clinical Chemistry, Isala Clinics, Zwolle, The Netherlands. 6. Diabeter, Rotterdam, The Netherlands.
Abstract
OBJECTIVES: To determine the prevalence of traditional cardiometabolic risk factors and to assess the effect of overweight/obesity on the occurrence of these risk factors in a cohort of children with type 1 diabetes mellitus (T1DM). STUDY DESIGN: Two hundred eighty-three consecutive patients (3 to 18 years of age) attending an outpatient clinic for T1DM care were included. The prevalence of cardiometabolic risk factors, the metabolic syndrome, and high alanine aminotransferase, were assessed before and after stratification for weight status. RESULTS: Of all children (median age, 12.8 years; interquartile range, 9.9 to 16.0; median diabetes duration, 5.3 years; interquartile range, 2.9 to 8.6), 38.5% were overweight/obese (Z-body mass index > or =1.1). Overall, median HbA1c levels were 8.2% (interquartile range, 7.4 to 9.8), and HbA1c > or =7.5% was present in 73.9%. Microalbuminuria was found in 17.7%, high triglycerides (>1.7 mmol/L) in 17.3%, high LDL-cholesterol (>2.6 mmol/L) in 28.6%, low HDL-cholesterol (<1.1 mmol/L) in 21.2%, and hypertension in 13.1% of patients. In the overweight/obese children with T1DM, versus normal-weight children, a higher prevalence of hypertension (23.9% vs 5.7%), the metabolic syndrome (25.7% vs 6.3%), and alanine aminotransferase >30 IU/L (15.6% vs 4.5%) was found (all P < .05). CONCLUSIONS: Overweight/obesity and cardiometabolic risk factors were highly prevalent in a pediatric cohort with T1DM. Hypertension, the metabolic syndrome, and high alanine aminotransferase were significantly more prevalent in overweight/obese compared with normal-weight children with T1DM. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVES: To determine the prevalence of traditional cardiometabolic risk factors and to assess the effect of overweight/obesity on the occurrence of these risk factors in a cohort of children with type 1 diabetes mellitus (T1DM). STUDY DESIGN: Two hundred eighty-three consecutive patients (3 to 18 years of age) attending an outpatient clinic for T1DM care were included. The prevalence of cardiometabolic risk factors, the metabolic syndrome, and high alanine aminotransferase, were assessed before and after stratification for weight status. RESULTS: Of all children (median age, 12.8 years; interquartile range, 9.9 to 16.0; median diabetes duration, 5.3 years; interquartile range, 2.9 to 8.6), 38.5% were overweight/obese (Z-body mass index > or =1.1). Overall, median HbA1c levels were 8.2% (interquartile range, 7.4 to 9.8), and HbA1c > or =7.5% was present in 73.9%. Microalbuminuria was found in 17.7%, high triglycerides (>1.7 mmol/L) in 17.3%, high LDL-cholesterol (>2.6 mmol/L) in 28.6%, low HDL-cholesterol (<1.1 mmol/L) in 21.2%, and hypertension in 13.1% of patients. In the overweight/obesechildren with T1DM, versus normal-weight children, a higher prevalence of hypertension (23.9% vs 5.7%), the metabolic syndrome (25.7% vs 6.3%), and alanine aminotransferase >30 IU/L (15.6% vs 4.5%) was found (all P < .05). CONCLUSIONS: Overweight/obesity and cardiometabolic risk factors were highly prevalent in a pediatric cohort with T1DM. Hypertension, the metabolic syndrome, and high alanine aminotransferase were significantly more prevalent in overweight/obese compared with normal-weight children with T1DM. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Amanda L P Sands; Laurie A Higgins; Sanjeev N Mehta; Tonja R Nansel; Leah M Lipsky; Lori M B Laffel Journal: J Diabetes Sci Technol Date: 2013-01-01
Authors: Shanshan Wang; Jamie L Crandell; Sarah C Couch; Irena B King; Jean M Lawrence; Dana Dabelea; Archana P Lamichhane; Grace Kim; Ronny A Bell; Shankuan Zhu; Elizabeth J Mayer-Davis Journal: J Nutr Date: 2015-01-21 Impact factor: 4.798