Jonatan R Ruiz1, Ruth Castillo2, Idoia Labayen3, Luis A Moreno4, Miguel García Fuentes5, Domingo González Lamuño5, Jesus L Alvarez Granda5, Alejandro Lucia6, Francisco B Ortega7. 1. Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden. Electronic address: ruizj@ugr.es. 2. Department of Basic Psychology, School of Psychology, University of Málaga, Spain. 3. Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain. 4. Department of Physiotherapy and Nursing, School of Health Sciences, University of Zaragoza, Zaragoza, Spain. 5. Department of Pediatrics, University of Cantabria, Santander, Spain. 6. Universidad Europea de Madrid, Madrid, Spain. 7. Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden; Department of Medical Physiology, School of Medicine, University of Granada, Spain.
Abstract
OBJECTIVE: To examine the individual and combined associations of ApoE and MTHFR 677C/T polymorphisms with cognitive performance in adolescents. STUDY DESIGN: The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability. RESULTS: We observed no differences in the cognitive performance study variables in adolescents carrying or not carrying the ApoE epsilon4 variant. Adolescents without the MTHFR 677TT genotype had significantly better cognitive performance than their TT peers. The analysis of the combined effect of these polymorphisms revealed that those individuals carrying both the ApoE epsilon4 variant and the MTHFR 677TT genotype had significantly worse cognitive performance than their peers with other genotype combinations. These findings were independent of sex, age pubertal status, socioeconomic status, physical activity, and skipping breakfast. CONCLUSIONS: The results of the present study suggest that the ApoE epsilon4 alone is not associated with cognitive performance in adolescents. Individuals with the MTHFR 677TT genotype had slightly impaired cognitive performance, whereas we observed a combined effect of both the ApoE epsilon4 variant and the MTHFR 677TT genotype on cognitive performance. More research is needed in larger population samples to corroborate our findings. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: To examine the individual and combined associations of ApoE and MTHFR677C/T polymorphisms with cognitive performance in adolescents. STUDY DESIGN: The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability. RESULTS: We observed no differences in the cognitive performance study variables in adolescents carrying or not carrying the ApoE epsilon4 variant. Adolescents without the MTHFR 677TT genotype had significantly better cognitive performance than their TT peers. The analysis of the combined effect of these polymorphisms revealed that those individuals carrying both the ApoE epsilon4 variant and the MTHFR 677TT genotype had significantly worse cognitive performance than their peers with other genotype combinations. These findings were independent of sex, age pubertal status, socioeconomic status, physical activity, and skipping breakfast. CONCLUSIONS: The results of the present study suggest that the ApoE epsilon4 alone is not associated with cognitive performance in adolescents. Individuals with the MTHFR 677TT genotype had slightly impaired cognitive performance, whereas we observed a combined effect of both the ApoE epsilon4 variant and the MTHFR 677TT genotype on cognitive performance. More research is needed in larger population samples to corroborate our findings. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Kala Y Kamdar; Kevin R Krull; Randa A El-Zein; Pim Brouwers; Brian S Potter; Lynnette L Harris; Suzanne Holm; Zoann Dreyer; Fernando Scaglia; Carol J Etzel; Melissa Bondy; M Fatih Okcu Journal: Pediatr Blood Cancer Date: 2011-05-25 Impact factor: 3.167
Authors: Gali H Weissberger; Daniel A Nation; Caroline P Nguyen; Mark W Bondi; S Duke Han Journal: Neurosci Biobehav Rev Date: 2018-08-17 Impact factor: 8.989
Authors: Brian J Piper; Alia L Yasen; Amy E Taylor; Jonatan R Ruiz; J William Gaynor; Catherine A Dayger; Marcela Gonzalez-Gross; Oh D Kwon; Lars-Göran Nilsson; Ian N M Day; Jacob Raber; Jeremy K Miller Journal: Laterality Date: 2012-06-21
Authors: Kang Ko; Min Soo Byun; Dahyun Yi; Jun Ho Lee; Chan Hyung Kim; Dong Young Lee Journal: Front Aging Neurosci Date: 2018-03-22 Impact factor: 5.750