OBJECTIVE: We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS: We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. For pericoronary fat evaluation, regions of interest were manually traced containing any fat surrounding a coronary artery segment, with the myocardial wall, the pericardial sac and other coronary segments as outer border. RESULTS: Per each doubling of pericoronary fat volume, we observed an 2.5-fold increase in the presence of plaque in the underlying coronary segment in unadjusted models (95% confidence interval [CI] 1.87-3.27, p<0.001), which remained after adjustment for traditional cardiovascular risk factors (odds ratio [OR] 3.07 [2.16-4.35], p<0.001) and when additionally accounting for overall pericardial fat volume (OR 2.68 [1.90-3.79], p<0.001). Associations were similar in all coronary artery segments and not related to the type of plaque (calcified or non-calcified, p<0.01 for all). CONCLUSION: Pericoronary fat is associated with atherosclerosis in the coronary arteries. Our results support the hypothesis that perivascular fat depots may function as a local endocrine risk factor in atherosclerosis development. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS: We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. For pericoronary fat evaluation, regions of interest were manually traced containing any fat surrounding a coronary artery segment, with the myocardial wall, the pericardial sac and other coronary segments as outer border. RESULTS: Per each doubling of pericoronary fat volume, we observed an 2.5-fold increase in the presence of plaque in the underlying coronary segment in unadjusted models (95% confidence interval [CI] 1.87-3.27, p<0.001), which remained after adjustment for traditional cardiovascular risk factors (odds ratio [OR] 3.07 [2.16-4.35], p<0.001) and when additionally accounting for overall pericardial fat volume (OR 2.68 [1.90-3.79], p<0.001). Associations were similar in all coronary artery segments and not related to the type of plaque (calcified or non-calcified, p<0.01 for all). CONCLUSION: Pericoronary fat is associated with atherosclerosis in the coronary arteries. Our results support the hypothesis that perivascular fat depots may function as a local endocrine risk factor in atherosclerosis development. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Balaji Tamarappoo; Damini Dey; Haim Shmilovich; Ryo Nakazato; Heidi Gransar; Victor Y Cheng; John D Friedman; Sean W Hayes; Louise E J Thomson; Piotr J Slomka; Alan Rozanski; Daniel S Berman Journal: JACC Cardiovasc Imaging Date: 2010-11
Authors: Haim Shmilovich; Damini Dey; Victor Y Cheng; Ronak Rajani; Ryo Nakazato; Yuka Otaki; Rine Nakanishi; Piotr J Slomka; Louise E J Thomson; Sean W Hayes; John D Friedman; Heidi Gransar; Nathan D Wong; Leslee J Shaw; Matthew Budoff; Alan Rozanski; Daniel S Berman Journal: Am J Cardiol Date: 2011-08-30 Impact factor: 2.778
Authors: Kirsti A Campbell; Michael J Lipinski; Amanda C Doran; Marcus D Skaflen; Valentin Fuster; Coleen A McNamara Journal: Circ Res Date: 2012-03-16 Impact factor: 17.367
Authors: Michael Brener; Kerunne Ketlogetswe; Matthew Budoff; Lisa P Jacobson; Xiuhong Li; Panteha Rezaeian; Aryabod Razipour; Frank J Palella; Lawrence Kingsley; Mallory D Witt; Richard T George; Wendy S Post Journal: AIDS Date: 2014-07-17 Impact factor: 4.177