AIMS: Few studies have examined very-low-density lipoprotein (VLDL) cholesterol as an independent risk factor of coronary heart disease (CHD) or its combined effects with coexisting cardiac risk factors. The current study examined the association between VLDL cholesterol and the risk of future CHD events. METHODS AND RESULTS: This study reports the association of VLDL cholesterol level and long-term CHD risk, as well as the combined effects of VLDL cholesterol and LDL cholesterol with other cardiovascular disease (CVD) risk factors. The cohort comprises 30,378 participants aged 35-64 years from 11 Chinese provinces. All participants were followed up annually until 2007. We found 20% of the sample population had elevated VLDL cholesterol>or=30 mg/dL. Elevated VLDL cholesterol levels were found to increase CHD risk by 2.19-3.36-fold in people with LDL cholesterol within the normal range and presenting no other major risk factors. This effect was exacerbated in those with elevated LDL cholesterol levels, and further increased CHD risk in those displaying three or more risk factors. The population-attributable risk proportion (PAR%) of CHD associated with VLDL cholesterol was calculated to be 17.3%, higher than that associated with LDL cholesterol alone. CONCLUSIONS: In a large Chinese cohort, elevated VLDL cholesterol was found to be significantly associated with elevated CHD risk, similar to that observed with LDL cholesterol. CHD risk was further amplified when elevated VLDL cholesterol was combined with elevated LDL cholesterol and/or the presence of major CVD risk factors. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
AIMS: Few studies have examined very-low-density lipoprotein (VLDL) cholesterol as an independent risk factor of coronary heart disease (CHD) or its combined effects with coexisting cardiac risk factors. The current study examined the association between VLDL cholesterol and the risk of future CHD events. METHODS AND RESULTS: This study reports the association of VLDL cholesterol level and long-term CHD risk, as well as the combined effects of VLDL cholesterol and LDL cholesterol with other cardiovascular disease (CVD) risk factors. The cohort comprises 30,378 participants aged 35-64 years from 11 Chinese provinces. All participants were followed up annually until 2007. We found 20% of the sample population had elevated VLDL cholesterol>or=30 mg/dL. Elevated VLDL cholesterol levels were found to increase CHD risk by 2.19-3.36-fold in people with LDL cholesterol within the normal range and presenting no other major risk factors. This effect was exacerbated in those with elevated LDL cholesterol levels, and further increased CHD risk in those displaying three or more risk factors. The population-attributable risk proportion (PAR%) of CHD associated with VLDL cholesterol was calculated to be 17.3%, higher than that associated with LDL cholesterol alone. CONCLUSIONS: In a large Chinese cohort, elevated VLDL cholesterol was found to be significantly associated with elevated CHD risk, similar to that observed with LDL cholesterol. CHD risk was further amplified when elevated VLDL cholesterol was combined with elevated LDL cholesterol and/or the presence of major CVD risk factors. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Kirsty E Waddington; George A Robinson; Leda Coelewij; Elvira Chocano; Thomas McDonnell; Filipa Farinha; Junjie Peng; Pierre Dönnes; Edward Smith; Sara Croca; Jyoti Bakshi; Maura Griffin; Andrew Nicolaides; Anisur Rahman; Elizabeth C Jury; Ines Pineda-Torra Journal: Arterioscler Thromb Vasc Biol Date: 2021-02-04 Impact factor: 10.514
Authors: Pekka Mäntyselkä; Leo Niskanen; Hannu Kautiainen; Juha Saltevo; Peter Würtz; Pasi Soininen; Antti J Kangas; Mika Ala-Korpela; Mauno Vanhala Journal: Lipids Health Dis Date: 2014-02-07 Impact factor: 3.876