OBJECTIVE: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders. STUDY DESIGN: Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease. RESULTS: Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004). CONCLUSION: Placental lesions correspond with different clinical presentations. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders. STUDY DESIGN: Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease. RESULTS:Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004). CONCLUSION: Placental lesions correspond with different clinical presentations. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Karen J Gibbins; Robert M Silver; Halit Pinar; Uma M Reddy; Corette B Parker; Vanessa Thorsten; Marian Willinger; Donald J Dudley; Radek Bukowski; George R Saade; Matthew A Koch; Deborah Conway; Carol J Hogue; Barbara J Stoll; Robert L Goldenberg Journal: Placenta Date: 2016-05-07 Impact factor: 3.481
Authors: Alison M Fung; Danielle L Wilson; Martha Lappas; Mark Howard; Maree Barnes; Fergal O'Donoghue; Stephen Tong; Helen Esdale; Gabrielle Fleming; Susan P Walker Journal: PLoS One Date: 2013-07-24 Impact factor: 3.240