BACKGROUND: The changes in liver blood flow associated with living donor liver transplantation (LDLT) in children have not yet been studied. The aim of the present study was to investigate changes in hepatic hemodynamics before and after pediatric partial liver transplantation. METHODS: In 7 pediatric recipients with congenital cholestasis and native liver Child-Pugh classes B and C, portal vein flow (PVF) and hepatic arterial flow (HAF) were measured using an ultrasonic transit time flow meter before removal of the native liver and after transplantation and compared with donor left PVF and donor left HAF. RESULTS: The mean portal contribution to total hepatic blood flow was markedly decreased in the recipient native liver compared with that in the donor (69% +/- 15% vs 32% +/- 15%; P = .0003) and after reperfusion changed to almost the same ratio as that in the donor liver (73% +/- 18%; P < .0001). CONCLUSION: The extreme imbalance between PVF and HAF that is common in implanted partial liver in adult LDLT recipients was not observed in pediatric LDLT. After transplantation of an appropriately sized liver graft, the portal contribution to total liver blood flow normalized to the value for normal liver.
BACKGROUND: The changes in liver blood flow associated with living donor liver transplantation (LDLT) in children have not yet been studied. The aim of the present study was to investigate changes in hepatic hemodynamics before and after pediatric partial liver transplantation. METHODS: In 7 pediatric recipients with congenital cholestasis and native liver Child-Pugh classes B and C, portal vein flow (PVF) and hepatic arterial flow (HAF) were measured using an ultrasonic transit time flow meter before removal of the native liver and after transplantation and compared with donor left PVF and donor left HAF. RESULTS: The mean portal contribution to total hepatic blood flow was markedly decreased in the recipient native liver compared with that in the donor (69% +/- 15% vs 32% +/- 15%; P = .0003) and after reperfusion changed to almost the same ratio as that in the donor liver (73% +/- 18%; P < .0001). CONCLUSION: The extreme imbalance between PVF and HAF that is common in implanted partial liver in adult LDLT recipients was not observed in pediatric LDLT. After transplantation of an appropriately sized liver graft, the portal contribution to total liver blood flow normalized to the value for normal liver.
Authors: Steffen Hartleif; Michael Schumm; Michaela Döring; Markus Mezger; Peter Lang; Marc H Dahlke; Joachim Riethmüller; Alfred Königsrainer; Rupert Handgretinger; Silvio Nadalin; Ekkehard Sturm Journal: Stem Cells Int Date: 2017-06-27 Impact factor: 5.443