BACKGROUND: Meniscal degeneration (MD) is a structural change of fibrous cartilage that is common in orthopaedic diagnostics and relevant for health insurance matters. So far, there has been neither a standardised scoring system nor an immunohistochemical marker for MD. MATERIAL AND METHOD: In this retrospective trial, the meniscal tissue of 60 patients was assessed immunohistochemically for NITEGE (G1 fragment of the proteoglycan aggrecan) expression. NITEGE expression was correlated with defined grades of MD: little (grade 0/1), medium (grade 2), or severe (grade 3). RESULTS: Detection of extracellular NITEGE deposits in grade 2 or 3 MD had a positive predictive value and specificity of 100%, whereas no deposits were found in grade 0/1 MD. Sensitivity in advanced MD was 55%. Detection of extracellular NITEGE correlated positively with the grade of degeneration, as did patient age and the grade of degeneration. The patient age of those with grade 0/1 MD was significantly lower than for grade 3 (p<0.0001). CONCLUSION: The thoroughly defined degeneration score (grade 1 - grade 3 MD) is suitable to assess the severity of degeneration. Extracellular NITEGE deposits can be regarded as an immunohistochemical marker for advanced (grades 2 and 3) MD.
BACKGROUND:Meniscal degeneration (MD) is a structural change of fibrous cartilage that is common in orthopaedic diagnostics and relevant for health insurance matters. So far, there has been neither a standardised scoring system nor an immunohistochemical marker for MD. MATERIAL AND METHOD: In this retrospective trial, the meniscal tissue of 60 patients was assessed immunohistochemically for NITEGE (G1 fragment of the proteoglycan aggrecan) expression. NITEGE expression was correlated with defined grades of MD: little (grade 0/1), medium (grade 2), or severe (grade 3). RESULTS: Detection of extracellular NITEGE deposits in grade 2 or 3 MD had a positive predictive value and specificity of 100%, whereas no deposits were found in grade 0/1 MD. Sensitivity in advanced MD was 55%. Detection of extracellular NITEGE correlated positively with the grade of degeneration, as did patient age and the grade of degeneration. The patient age of those with grade 0/1 MD was significantly lower than for grade 3 (p<0.0001). CONCLUSION: The thoroughly defined degeneration score (grade 1 - grade 3 MD) is suitable to assess the severity of degeneration. Extracellular NITEGE deposits can be regarded as an immunohistochemical marker for advanced (grades 2 and 3) MD.
Authors: M W Lark; E K Bayne; J Flanagan; C F Harper; L A Hoerrner; N I Hutchinson; I I Singer; S A Donatelli; J R Weidner; H R Williams; R A Mumford; L S Lohmander Journal: J Clin Invest Date: 1997-07-01 Impact factor: 14.808
Authors: E C Arner; M A Pratta; C P Decicco; C B Xue; R C Newton; J M Trzaskos; R L Magolda; M D Tortorella Journal: Ann N Y Acad Sci Date: 1999-06-30 Impact factor: 5.691
Authors: Manas K Majumdar; Roger Askew; Scott Schelling; Nancy Stedman; Tracey Blanchet; Bei Hopkins; Elisabeth A Morris; Sonya S Glasson Journal: Arthritis Rheum Date: 2007-11
Authors: Kalpa P Patel; John D Sandy; Koji Akeda; Kei Miyamoto; Takehide Chujo; Howard S An; Koichi Masuda Journal: Spine (Phila Pa 1976) Date: 2007-11-01 Impact factor: 3.468
Authors: J Petzold; R Casadonte; M Otto; M Kriegsmann; M Granrath; A Baltzer; J Vogel; P Drees; S Deininger; M Becker; J Kriegsmann Journal: Z Rheumatol Date: 2015-06 Impact factor: 1.372
Authors: C Pauli; S P Grogan; S Patil; S Otsuki; A Hasegawa; J Koziol; M K Lotz; D D D'Lima Journal: Osteoarthritis Cartilage Date: 2011-06-01 Impact factor: 6.576
Authors: Susanne Rein; Veit Krenn; Elisabet Hagert; Marc Garcia-Elias; Alex Lluch; Thomas Kremer; Manuel Semisch Journal: Arch Orthop Trauma Surg Date: 2021-02-06 Impact factor: 3.067
Authors: Michael Kreinest; Gregor Reisig; Philipp Ströbel; Stefan Fickert; Joachim Brade; Gunther Wennemuth; Peter Lipp; Markus L Schwarz Journal: Comp Med Date: 2016-02 Impact factor: 0.982
Authors: Michael Kreinest; Gregor Reisig; Philipp Ströbel; Dietmar Dinter; Ulrike Attenberger; Peter Lipp; Markus Schwarz Journal: PLoS One Date: 2016-07-19 Impact factor: 3.240
Authors: Thelonius Hawellek; Jan Hubert; Sandra Hischke; Matthias Krause; Jessica Bertrand; Burkhard C Schmidt; Andreas Kronz; Klaus Püschel; Wolfgang Rüther; Andreas Niemeier Journal: Arthritis Res Ther Date: 2018-05-30 Impact factor: 5.156