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Literature DB >> 20221288

Stress to the rescue: is hormesis a 'cure' for aging?

Abstract

Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis as an effective anti-ageing strategy we turn to a simple model organism for insight. In this review we explore what can be predicted about the usefulness of hormetic treatments in humans based upon studies conducted in the soil nematode Caenorhabditis elegans.

Entities: Species

Keywords: Age-related disease; Aging; C. elegans; hormesis; intervention

Year: 2009 PMID： 20221288 PMCID： PMC2836152 DOI： 10.2203/dose-response.09-031.Olsen

Source DB: PubMed Journal: Dose Response ISSN： 1559-3258 Impact factor: 2.658

20 in total

1. Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans.

Authors: Zhixin Wu; Julie V Smith; Vijayakumar Paramasivam; Peter Butko; Ikhlas Khan; James R Cypser; Yuan Luo
Journal: Cell Mol Biol (Noisy-le-grand) Date: 2002-09 Impact factor: 1.770

2. Lifespan extension in Caenorhabditis elegans by complete removal of food.

Authors: Tammi L Kaeberlein; Erica D Smith; Mitsuhiro Tsuchiya; K Linnea Welton; James H Thomas; Stanley Fields; Brian K Kennedy; Matt Kaeberlein
Journal: Aging Cell Date: 2006-11-01 Impact factor: 9.304

3. Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments.

Authors: Anders Olsen; Maithili C Vantipalli; Gordon J Lithgow
Journal: Biogerontology Date: 2006-07-07 Impact factor: 4.277

4. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.

Authors: Ken Yokoyama; Keiji Fukumoto; Tatsuya Murakami; Shin-ichi Harada; Ryuji Hosono; Renu Wadhwa; Youji Mitsui; Shoji Ohkuma
Journal: FEBS Lett Date: 2002-04-10 Impact factor: 4.124

5. Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.

Authors: Custer C Deocaris; Kazunari Taira; Sunil C Kaul; Renu Wadhwa
Journal: FEBS Lett Date: 2005-01-31 Impact factor: 4.124

6. An antidepressant that extends lifespan in adult Caenorhabditis elegans.

Authors: Michael Petrascheck; Xiaolan Ye; Linda B Buck
Journal: Nature Date: 2007-11-22 Impact factor: 49.962

Review 7. Hormesis: a promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders.

Authors: Ann M Marini; Hong Jiang; Hongna Pan; Xuan Wu; Robert H Lipsky
Journal: Ageing Res Rev Date: 2007-08-24 Impact factor: 10.895

8. The managed immune system: protecting the womb to delay the tomb.

Authors: Rodney R Dietert; Michael S Piepenbrink
Journal: Hum Exp Toxicol Date: 2008-02 Impact factor: 2.903

Review 9. Turning anti-ageing genes against cancer.

Authors: Valter D Longo; Michael R Lieber; Jan Vijg
Journal: Nat Rev Mol Cell Biol Date: 2008-11 Impact factor: 94.444

10. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Authors: Lizzia Raffaghello; Changhan Lee; Fernando M Safdie; Min Wei; Federica Madia; Giovanna Bianchi; Valter D Longo
Journal: Proc Natl Acad Sci U S A Date: 2008-03-31 Impact factor: 11.205

4 in total

Review 1. Promoting longevity by maintaining metabolic and proliferative homeostasis.

Authors: Lifen Wang; Jason Karpac; Heinrich Jasper
Journal: J Exp Biol Date: 2014-01-01 Impact factor: 3.312

2. "Is hormesis applicable as a pro-healthy aging intervention in mammals and human beings, and how?" Introduction to a special issue of Dose-Response.

Authors: Eric Le Bourg; Suresh I S Rattan
Journal: Dose Response Date: 2009-12-11 Impact factor: 2.658

3. Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle.

Authors: Alistair V Nunn; Geoffrey W Guy; James S Brodie; Jimmy D Bell
Journal: Nutr Metab (Lond) Date: 2010-12-09 Impact factor: 4.169

4. Hormesis results in trade-offs with immunity.

Authors: Colin D McClure; Weihao Zhong; Vicky L Hunt; Fiona M Chapman; Fiona V Hill; Nicholas K Priest
Journal: Evolution Date: 2014-06-20 Impact factor: 3.694

4 in total