OBJECTIVE: To analyze the prevalence of the metabolic syndrome (MetS) defined by three sets of Adult Treatment Panel III (ATPIII)-derived criteria, and the ability of each definition to identify insulin-resistance (IR) in a wide cohort of outpatient children. SUBJECTS AND METHODS: Seven hundred and twenty-four children consecutively observed in the Outpatient Pediatric Clinic of Pozzuoli Hospital during the period 2004-2009 were included in the study. Diagnosis of the MetS was made using three definitions: Cook, Jolliffe (which adopt age- and gender-specific cut-points) and de Ferranti. Insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). IR was defined by the 90th percentile of HOMA-IR in healthy non-obese Italian children grouped by gender and Tanner stage. The ability of each definition to identify IR was evaluated in terms of sensitivity and specificity. RESULTS: The prevalence of the MetS in the overall cohort was 11, 12 and 24% using Cook, Jolliffe and de Ferranti criteria, respectively. Sensitivity and specificity in relation to IR were 19 and 94% with Cook criteria, 21 and 92% with Jolliffe criteria, and 39 and 84% with de Ferranti criteria. CONCLUSIONS: The prevalence of the MetS in children increases with increasing body weight. Among the three definitions analyzed, de Ferranti identifies a larger number of children with the MetS. The prediction of IR is weak with all definitions; on the contrary, the absence of MetS identifies fairly well children with low degree of IR.
OBJECTIVE: To analyze the prevalence of the metabolic syndrome (MetS) defined by three sets of Adult Treatment Panel III (ATPIII)-derived criteria, and the ability of each definition to identify insulin-resistance (IR) in a wide cohort of outpatientchildren. SUBJECTS AND METHODS: Seven hundred and twenty-four children consecutively observed in the Outpatient Pediatric Clinic of Pozzuoli Hospital during the period 2004-2009 were included in the study. Diagnosis of the MetS was made using three definitions: Cook, Jolliffe (which adopt age- and gender-specific cut-points) and de Ferranti. Insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). IR was defined by the 90th percentile of HOMA-IR in healthy non-obese Italian children grouped by gender and Tanner stage. The ability of each definition to identify IR was evaluated in terms of sensitivity and specificity. RESULTS: The prevalence of the MetS in the overall cohort was 11, 12 and 24% using Cook, Jolliffe and de Ferranti criteria, respectively. Sensitivity and specificity in relation to IR were 19 and 94% with Cook criteria, 21 and 92% with Jolliffe criteria, and 39 and 84% with de Ferranti criteria. CONCLUSIONS: The prevalence of the MetS in children increases with increasing body weight. Among the three definitions analyzed, de Ferranti identifies a larger number of children with the MetS. The prediction of IR is weak with all definitions; on the contrary, the absence of MetS identifies fairly well children with low degree of IR.
Authors: Julia Steinberger; Stephen R Daniels; Robert H Eckel; Laura Hayman; Robert H Lustig; Brian McCrindle; Michele L Mietus-Snyder Journal: Circulation Date: 2009-01-12 Impact factor: 29.690
Authors: E Cacciari; S Milani; A Balsamo; E Spada; G Bona; L Cavallo; F Cerutti; L Gargantini; N Greggio; G Tonini; A Cicognani Journal: J Endocrinol Invest Date: 2006 Jul-Aug Impact factor: 4.256
Authors: Sarah D de Ferranti; Kimberlee Gauvreau; David S Ludwig; Ellis J Neufeld; Jane W Newburger; Nader Rifai Journal: Circulation Date: 2004-10-11 Impact factor: 29.690
Authors: A Sartorio; F Agosti; A De Col; E Compri; G Grugni; W Siegfried; F Adorni; C L Lafortuna Journal: J Endocrinol Invest Date: 2011-10 Impact factor: 4.256
Authors: F Prodam; R Ricotti; G Genoni; S Parlamento; A Petri; C Balossini; S Savastio; G Bona; S Bellone Journal: J Endocrinol Invest Date: 2012-11-27 Impact factor: 4.256