Literature DB >> 20219880

Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea.

Jose Flores1, Herbert L DuPont, Mercedes Paredes-Paredes, M Magdalena Aguirre-Garcia, Araceli Rojas, Alexei Gonzalez, Pablo C Okhuysen.   

Abstract

Enterotoxigenic Escherichia coli (ETEC), which produces heat-labile toxin (LT), is a common cause of travelers' diarrhea (TD). The B subunit of ETEC LT is immunologically related to the B subunit of Vibrio cholerae toxin (CT). In this pilot study we evaluated the whole-blood gamma interferon response to CT B in 17 U.S. adults traveling to Mexico. Only one of nine subjects who demonstrated a cellular immune response as determined by whole-blood gamma interferon production to CT B on arrival to Mexico developed diarrhea, whereas five of eight without a cellular response developed diarrhea. Markers of the cellular immune response to ETEC LT could help in identifying individuals immune to ETEC LT, and these markers deserve additional study.

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Year:  2010        PMID： 20219880      PMCID： PMC2863377          DOI： 10.1128/CVI.00486-09

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  12 in total

1.  Characterization of enterotoxigenic Escherichia coli strains in patients with travelers' diarrhea acquired in Guadalajara, Mexico, 1992-1997.

Authors:  Z D Jiang; J J Mathewson; C D Ericsson; A M Svennerholm; C Pulido; H L DuPont
Journal:  J Infect Dis       Date:  2000-02       Impact factor: 5.226

2.  Natural history of enteroaggregative and enterotoxigenic Escherichia coli infection among US travelers to Guadalajara, Mexico.

Authors:  Javier A Adachi; Charles D Ericsson; Zhi-Dong Jiang; Margaret W DuPont; Sanjay R Pallegar; Herbert L DuPont
Journal:  J Infect Dis       Date:  2002-05-17       Impact factor: 5.226

3.  Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial.

Authors:  Sarah A Frech; Herbert L Dupont; A Louis Bourgeois; Robin McKenzie; Jaime Belkind-Gerson; Jose F Figueroa; Pablo C Okhuysen; Norma H Guerrero; Francisco G Martinez-Sandoval; Juan Hm Meléndez-Romero; Zhi-Dong Jiang; Edwin J Asturias; Jane Halpern; Olga R Torres; Ana S Hoffman; Christina P Villar; Raniya N Kassem; David C Flyer; Bo H Andersen; Kazem Kazempour; Sally A Breisch; Gregory M Glenn
Journal:  Lancet       Date:  2008-06-14       Impact factor: 79.321

4.  Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial.

Authors:  J D Clemens; D A Sack; J R Harris; J Chakraborty; P K Neogy; B Stanton; N Huda; M U Khan; B A Kay; M R Khan
Journal:  J Infect Dis       Date:  1988-08       Impact factor: 5.226

5.  Preexisting antibodies to homologous colonization factors and heat-labile toxin in serum, and the risk to develop enterotoxigenic Escherichia coli-associated diarrhea.

Authors:  Joshua Tobias; Kerstin Andersson; Anya Bialik; Dani Cohen
Journal:  Diagn Microbiol Infect Dis       Date:  2007-10-25       Impact factor: 2.803

6.  Influence of host interleukin-10 polymorphisms on development of traveler's diarrhea due to heat-labile enterotoxin-producing Escherichia coli in travelers from the United States who are visiting Mexico.

Authors:  Jose Flores; Herbert L DuPont; Stephanie A Lee; Jaime Belkind-Gerson; Mercedes Paredes; Jamal A Mohamed; Lisa Y Armitige; Dong-Chuan Guo; Pablo C Okhuysen
Journal:  Clin Vaccine Immunol       Date:  2008-06-25

7.  Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.

Authors:  I Nakagawa; I Takahashi; H Kiyono; J R McGhee; S Hamada
Journal:  J Infect Dis       Date:  1996-06       Impact factor: 5.226

8.  Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells.

Authors:  Amber M Johnson; Radhey S Kaushik; David H Francis; James M Fleckenstein; Philip R Hardwidge
Journal:  J Bacteriol       Date:  2008-10-31       Impact factor: 3.490

9.  Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin.

Authors:  W S Dallas; S Falkow
Journal:  Nature       Date:  1980-12-04       Impact factor: 49.962

10.  Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit.

Authors:  L de Haan; W R Verweij; I K Feil; M Holtrop; W G Hol; E Agsteribbe; J Wilschut
Journal:  Immunology       Date:  1998-07       Impact factor: 7.397
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