Do measures of schizotypal personality provide non-clinical analogues of schizophrenic symptomatology?

This study tested the assumption that measures of schizotypal personality provide non-clinical analogues of the heterogeneous symptomatology found in the schizophrenic disorder. The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) was administered to schizophrenic patients and healthy controls, and measures of symptomatology from the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were assessed in the patient group. Schizophrenic patients scored significantly higher than controls on O-LIFE measures of positive, negative and disorganised schizotypy, while no difference in Impulsive Nonconformity was observed. In the patient group, SAPS positive symptomatology was significantly correlated with O-LIFE positive schizotypy (Unusual Experiences) and Cognitive Disorganisation. However, there was no significant relationship between SAPS/SANS disorganisation and O-LIFE Cognitive Disorganisation, or between the SANS negative factor score and O-LIFE Introvertive Anhedonia. The results suggest that the O-LIFE is a valid tool for assessing schizotypal personality in both schizophrenic patients and healthy controls. However, while the O-LIFE measure of positive schizotypy may correspond with SAPS/SANS positive schizophrenic symptomatology, the negative and disorganised subscales may not be analogous to their SAPS/SANS counterparts. There is also evidence to question the acceptability of Impulsive Nonconformity as a true schizophrenia-like construct. Copyright (c) 2009 Elsevier Ltd. All rights reserved.