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Literature DB >> 20219172

Polyglutamylation: the GLU that makes microtubules sticky.

Abstract

The beating of cilia and flagella depends on microtubule sliding generated by dynein motors, but the interaction of these motors with their tracks is still under investigation. New evidence suggests that some dynein motors will not function properly unless their track has been modified by a specific post-translational modification.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 20219172 PMCID： PMC3322424 DOI： 10.1016/j.cub.2010.01.008

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

20 in total

1. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation.

Authors: C Bonnet; D Boucher; S Lazereg; B Pedrotti; K Islam; P Denoulet; J C Larcher
Journal: J Biol Chem Date: 2001-01-22 Impact factor: 5.157

2. The C-terminus of tubulin increases cytoplasmic dynein and kinesin processivity.

Authors: Z Wang; M P Sheetz
Journal: Biophys J Date: 2000-04 Impact factor: 4.033

Review 3. Cytoskeleton: functions for tubulin modifications at last.

Authors: J Rosenbaum
Journal: Curr Biol Date: 2000-11-02 Impact factor: 10.834

4. Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena.

Authors: Virginie Redeker; Nicolette Levilliers; Emilie Vinolo; Jean Rossier; Danielle Jaillard; Dylan Burnette; Jacek Gaertig; Marie-Hélène Bré
Journal: J Biol Chem Date: 2004-10-18 Impact factor: 5.157

5. An axonemal dynein particularly important for flagellar movement at high viscosity. Implications from a new Chlamydomonas mutant deficient in the dynein heavy chain gene DHC9.

Authors: Toshiki Yagi; Itsushi Minoura; Akiko Fujiwara; Ryo Saito; Takuo Yasunaga; Masafumi Hirono; Ritsu Kamiya
Journal: J Biol Chem Date: 2005-10-18 Impact factor: 5.157

Polyglutamylation: the GLU that makes microtubules sticky.

1. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation.

2. The C-terminus of tubulin increases cytoplasmic dynein and kinesin processivity.

Review 3. Cytoskeleton: functions for tubulin modifications at last.

4. Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena.

5. An axonemal dynein particularly important for flagellar movement at high viscosity. Implications from a new Chlamydomonas mutant deficient in the dynein heavy chain gene DHC9.

6. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.

7. The molecular architecture of axonemes revealed by cryoelectron tomography.

8. Functional coordination of intraflagellar transport motors.

9. Distribution of polyglutamylated tubulin in the flagellar apparatus of green flagellates.

10. The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.

Review 1. Epigenetically Mediated Ciliogenesis and Cell Cycle Regulation, and Their Translational Potential.