Literature DB >> 20218908

CalDAG-GEFI and platelet activation.

Lucia Stefanini1, Wolfgang Bergmeier.   

Abstract

Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which (a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid Ca(2+)-dependent platelet activation, (b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C and the Gi-coupled receptor for ADP, P2Y12, and (c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.

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Year:  2010        PMID： 20218908      PMCID： PMC4119791          DOI： 10.3109/09537101003639931

Source DB:  PubMed          Journal:  Platelets        ISSN： 0953-7104            Impact factor:   3.862


  21 in total

1.  Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Authors:  Jaewon Han; Chinten James Lim; Naohide Watanabe; Alessandra Soriani; Boris Ratnikov; David A Calderwood; Wilma Puzon-McLaughlin; Esther M Lafuente; Vassiliki A Boussiotis; Sanford J Shattil; Mark H Ginsberg
Journal:  Curr Biol       Date:  2006-09-19       Impact factor: 10.834

2.  Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis.

Authors:  Magdalena J Lorenowicz; Janine van Gils; Martin de Boer; Peter L Hordijk; Mar Fernandez-Borja
Journal:  J Leukoc Biol       Date:  2006-08-29       Impact factor: 4.962

3.  The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3.

Authors:  Bruno Bernardi; Gianni F Guidetti; Francesca Campus; Jill R Crittenden; Ann M Graybiel; Cesare Balduini; Mauro Torti
Journal:  Blood       Date:  2005-12-15       Impact factor: 22.113

4.  RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.

Authors:  J O Ebinu; D A Bottorff; E Y Chan; S L Stang; R J Dunn; J C Stone
Journal:  Science       Date:  1998-05-15       Impact factor: 47.728

5.  Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.

Authors:  Jill R Crittenden; Ippolita Cantuti-Castelvetri; Esen Saka; Christine E Keller-McGandy; Ledia F Hernandez; Lauren R Kett; Anne B Young; David G Standaert; Ann M Graybiel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-26       Impact factor: 11.205

6.  Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

Authors:  Wolfgang Bergmeier; Tobias Goerge; Hong-Wei Wang; Jill R Crittenden; Andrew C W Baldwin; Stephen M Cifuni; David E Housman; Ann M Graybiel; Denisa D Wagner
Journal:  J Clin Invest       Date:  2007-05-10       Impact factor: 14.808

7.  A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

Authors:  H Kawasaki; G M Springett; S Toki; J J Canales; P Harlan; J P Blumenstiel; E J Chen; I A Bany; N Mochizuki; A Ashbacher; M Matsuda; D E Housman; A M Graybiel
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

8.  CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.

Authors:  Stephen M Cifuni; Denisa D Wagner; Wolfgang Bergmeier
Journal:  Blood       Date:  2008-06-10       Impact factor: 22.113

9.  Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets.

Authors:  Mary K Boudreaux; James L Catalfamo; Marion Klok
Journal:  Transl Res       Date:  2007-05-25       Impact factor: 7.012

10.  Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

Authors:  Joanne E Johnson; Rebecca E Goulding; Ziwei Ding; Amir Partovi; Kira V Anthony; Nadine Beaulieu; Ghazaleh Tazmini; Rosemary B Cornell; Robert J Kay
Journal:  Biochem J       Date:  2007-09-01       Impact factor: 3.857
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  17 in total

Review 1.  P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells.

Authors:  Christian Gachet
Journal:  Purinergic Signal       Date:  2012-04-11       Impact factor: 3.765

2.  Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis.

Authors:  Benjamin E Tourdot; Stanley Conaway; Katrin Niisuke; Leonard C Edelstein; Paul F Bray; Michael Holinstat
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-10-02       Impact factor: 8.311

3.  A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.

Authors:  Jinqi Ren; Aaron A Cook; Wolfgang Bergmeier; John Sondek
Journal:  Biochem Biophys Res Commun       Date:  2016-04-21       Impact factor: 3.575

4.  Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.

Authors:  Agnes Czikora; Noemi Kedei; Heather Kalish; Peter M Blumberg
Journal:  Biochim Biophys Acta Biomembr       Date:  2017-09-11       Impact factor: 3.747

5.  CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

Authors:  Yacine Boulaftali; A Phillip Owens; Ashley Beale; Raymond Piatt; Caterina Casari; Robert H Lee; Pamela B Conley; David S Paul; Nigel Mackman; Wolfgang Bergmeier
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-03-17       Impact factor: 8.311

6.  JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.

Authors:  Bärbel Edelmann; Nibedita Gupta; Tina M Schnoeder; Anja M Oelschlegel; Khurrum Shahzad; Jürgen Goldschmidt; Lars Philipsen; Soenke Weinert; Aniket Ghosh; Felix C Saalfeld; Subbaiah Chary Nimmagadda; Peter Müller; Rüdiger Braun-Dullaeus; Juliane Mohr; Denise Wolleschak; Stefanie Kliche; Holger Amthauer; Florian H Heidel; Burkhart Schraven; Berend Isermann; Andreas J Müller; Thomas Fischer
Journal:  J Clin Invest       Date:  2018-07-19       Impact factor: 14.808

7.  RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

Authors:  Lucia Stefanini; David S Paul; Raymond F Robledo; E Ricky Chan; Todd M Getz; Robert A Campbell; Daniel O Kechele; Caterina Casari; Raymond Piatt; Kathleen M Caron; Nigel Mackman; Andrew S Weyrich; Matthew C Parrott; Yacine Boulaftali; Mark D Adams; Luanne L Peters; Wolfgang Bergmeier
Journal:  J Clin Invest       Date:  2015-02-23       Impact factor: 14.808

8.  Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.

Authors:  Agnes Czikora; Daniel J Lundberg; Adelle Abramovitz; Nancy E Lewin; Noemi Kedei; Megan L Peach; Xiaoling Zhou; Raymond C Merritt; Elizabeth A Craft; Derek C Braun; Peter M Blumberg
Journal:  J Biol Chem       Date:  2016-03-28       Impact factor: 5.157

Review 9.  Platelets and cancer: a casual or causal relationship: revisited.

Authors:  David G Menter; Stephanie C Tucker; Scott Kopetz; Anil K Sood; John D Crissman; Kenneth V Honn
Journal:  Cancer Metastasis Rev       Date:  2014-03       Impact factor: 9.264

10.  The road to ERK activation: Do neurons take alternate routes?

Authors:  Nadiatou Miningou; Kim T Blackwell
Journal:  Cell Signal       Date:  2020-01-13       Impact factor: 4.315
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