Literature DB >> 20217571

Determination of alternate splicing events using the Affymetrix Exon 1.0 ST arrays.

Sita Subbaram1, Marcy Kuentzel, David Frank, C Michael Dipersio, Sridar V Chittur.   

Abstract

Alternative splicing plays an important role in regulation of normal cellular function. Alternative splicing of pre-mRNA leads to the diversity of downstream protein products in the cell. The Affymetrix Exon arrays allow for a high throughput evaluation of the differences in spliced mRNA expressed in a biological system. In this study, we describe a method using this technology to study the generation of alternative mRNA transcripts in breast cancer cells that differ in the levels of a particular integrin, alpha3beta1.

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Year:  2010        PMID： 20217571      PMCID： PMC4695213          DOI： 10.1007/978-1-60761-663-4_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

1.  An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.

Authors:  John M Lamar; Kevin M Pumiglia; C Michael DiPersio
Journal:  Cancer Res       Date:  2008-09-15       Impact factor: 12.701

2.  Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression.

Authors:  Vandana Iyer; Kevin Pumiglia; C Michael DiPersio
Journal:  J Cell Sci       Date:  2005-02-22       Impact factor: 5.285

3.  Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5).

Authors:  Philip M Carpenter; Anh V Dao; Zahida S Arain; Michelle K Chang; Hoa P Nguyen; Shehla Arain; Jessica Wang-Rodriguez; Soon-Young Kwon; Sharon P Wilczynski
Journal:  Mol Cancer Res       Date:  2009-04-07       Impact factor: 5.852

4.  Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3.

Authors:  Kara Mitchell; Charles Szekeres; Vincenzo Milano; Kimberly B Svenson; Marit Nilsen-Hamilton; Jordan A Kreidberg; C Michael DiPersio
Journal:  J Cell Sci       Date:  2009-05-12       Impact factor: 5.285

5.  Laminin 5 expression in metaplastic breast carcinomas.

Authors:  Philip M Carpenter; Jessica Wang-Rodriguez; Owen T M Chan; Sharon P Wilczynski
Journal:  Am J Surg Pathol       Date:  2008-03       Impact factor: 6.394

6.  Probe selection and expression index computation of Affymetrix Exon Arrays.

Authors:  Yi Xing; Karen Kapur; Wing Hung Wong
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240

7.  Discovery of tissue-specific exons using comprehensive human exon microarrays.

Authors:  Tyson A Clark; Anthony C Schweitzer; Tina X Chen; Michelle K Staples; Gang Lu; Hui Wang; Alan Williams; John E Blume
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583
  7 in total
  3 in total

Review 1.  Integrin α3β1 as a breast cancer target.

Authors:  Sita Subbaram; C Michael Dipersio
Journal:  Expert Opin Ther Targets       Date:  2011-08-13       Impact factor: 6.902

2.  Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.

Authors:  Musa A Hassan; Jeroen P J Saeij
Journal:  Bioessays       Date:  2014-08-29       Impact factor: 4.345

3.  Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.

Authors:  Filipe Gracio; Brian Burford; Patrycja Gazinska; Anca Mera; Aisyah Mohd Noor; Pierfrancesco Marra; Cheryl Gillett; Anita Grigoriadis; Sarah Pinder; Andrew Tutt; Emanuele de Rinaldis
Journal:  Sci Rep       Date:  2017-01-06       Impact factor: 4.379
  3 in total

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