Literature DB >> 20217459

CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.

Yoji Yamashita1, Isao Kasugai, Masami Sato, Nobuhiro Tanuma, Ikuro Sato, Miyuki Nomura, Katsumi Yamashita, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga, Ryuichi Katakura, Hiroshi Shima.   

Abstract

Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.

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Year:  2010        PMID： 20217459     DOI： 10.1007/s11060-010-0147-3

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  13 in total

1.  A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

Authors:  Marie-Christine Brezak; Muriel Quaranta; Odile Mondésert; Marie-Odile Galcera; Olivier Lavergne; Frédéric Alby; Martine Cazales; Véronique Baldin; Christophe Thurieau; Jeremiath Harnett; Christophe Lanco; Philip G Kasprzyk; Gregoire P Prevost; Bernard Ducommun
Journal:  Cancer Res       Date:  2004-05-01       Impact factor: 12.701

2.  Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

Authors:  Marie-Christine Brezak; Muriel Quaranta; Marie-Odile Contour-Galcera; Olivier Lavergne; Odile Mondesert; Pierrïck Auvray; Philip G Kasprzyk; Gregoire P Prevost; Bernard Ducommun
Journal:  Mol Cancer Ther       Date:  2005-09       Impact factor: 6.261

3.  Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status.

Authors:  Mário H G Faria; Bronner P A Gonçalves; Régia M do S V do Patrocínio; Manoel O de Moraes-Filho; Silvia H B Rabenhorst
Journal:  Neuropathology       Date:  2006-12       Impact factor: 1.906

4.  Prognostic significance of CDC25B expression in gliomas.

Authors:  H Nakabayashi; M Hara; K Shimizu
Journal:  J Clin Pathol       Date:  2006-07       Impact factor: 3.411

Review 5.  The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas.

Authors:  Anne Linn Johannessen; Sverre Helge Torp
Journal:  Pathol Oncol Res       Date:  2006-09-23       Impact factor: 3.201

6.  Gene expression profiling and genetic markers in glioblastoma survival.

Authors:  Jeremy N Rich; Christopher Hans; Beatrix Jones; Edwin S Iversen; Roger E McLendon; B K Ahmed Rasheed; Adrian Dobra; Holly K Dressman; Darell D Bigner; Joseph R Nevins; Mike West
Journal:  Cancer Res       Date:  2005-05-15       Impact factor: 12.701

Review 7.  In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets.

Authors:  Hiroaki Kiyokawa; Dipankar Ray
Journal:  Anticancer Agents Med Chem       Date:  2008-12       Impact factor: 2.505

Review 8.  Genetic pathways to primary and secondary glioblastoma.

Authors:  Hiroko Ohgaki; Paul Kleihues
Journal:  Am J Pathol       Date:  2007-05       Impact factor: 4.307

Review 9.  The when and wheres of CDC25 phosphatases.

Authors:  Rose Boutros; Christine Dozier; Bernard Ducommun
Journal:  Curr Opin Cell Biol       Date:  2006-02-17       Impact factor: 8.382

10.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728
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  17 in total

1.  Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.

Authors:  Mireia Náger; Maria Santacana; Deepshikha Bhardwaj; Joan Valls; Isidre Ferrer; Pere Nogués; Carles Cantí; Judit Herreros
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

2.  Expression of NF45 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth.

Authors:  Qingfeng Huang; Xiaojuan He; Xiaojun Qiu; Xianchen Liu; Guan Sun; Jun Guo; Zongmei Ding; Lixiang Yang; Na Ban; Tao Tao; Dongling Wang
Journal:  Tumour Biol       Date:  2014-07-16

3.  Knockdown of DIXDC1 Inhibits the Proliferation and Migration of Human Glioma Cells.

Authors:  Jianguo Chen; Chaoyan Shen; Jinlong Shi; Jianhong Shen; Wenjuan Chen; Jie Sun; Shaocheng Fan; Yuanqi Bei; Peng Xu; Hao Chang; Rui Jiang; Lu Hua; Bin Ji; Qingfeng Huang
Journal:  Cell Mol Neurobiol       Date:  2016-11-05       Impact factor: 5.046

4.  MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a.

Authors:  Ya-Ru Fu; Xi-Juan Liu; Xiao-Jun Li; Zhang-zhou Shen; Bo Yang; Cong-Cong Wu; Jia-Fu Li; Ling-Feng Miao; Han-Qing Ye; Guan-Hua Qiao; Simon Rayner; Stéphane Chavanas; Christian Davrinche; William J Britt; Qiyi Tang; Michael McVoy; Edward Mocarski; Min-Hua Luo
Journal:  J Virol       Date:  2014-11-05       Impact factor: 5.103

5.  Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.

Authors:  Sreelatha Gopinath; Kiranmai Alapati; Rama Rao Malla; Christopher S Gondi; Sanjeeva Mohanam; Dzung H Dinh; Jasti S Rao
Journal:  Mol Oncol       Date:  2011-07-26       Impact factor: 6.603

6.  CHD1L Regulates Cell Cycle, Apoptosis, and Migration in Glioma.

Authors:  Jie Sun; Li Zhang; Hongyu Zhao; Xiaojun Qiu; Wenjuan Chen; Donglin Wang; Na Ban; Shaochen Fan; Chaoyan Shen; Xiaojie Xia; Bin Ji; Yuchan Wang
Journal:  Cell Mol Neurobiol       Date:  2015-07-11       Impact factor: 5.046

7.  The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.

Authors:  Xiaoqian Liu; Wen Zong; Tangliang Li; Yujun Wang; Xingzhi Xu; Zhong-Wei Zhou; Zhao-Qi Wang
Journal:  EMBO J       Date:  2017-11-17       Impact factor: 11.598

8.  Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids.

Authors:  Hiroko Tabunoki; Naoki Saito; Khanit Suwanborirux; Kornvika Charupant; Jun-Ichi Satoh
Journal:  Cancer Cell Int       Date:  2012-04-11       Impact factor: 5.722

9.  Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme.

Authors:  Qingyang Liu; Chuanbao Zhang; Guofo Ma; Quangeng Zhang
Journal:  Oncol Lett       Date:  2013-12-06       Impact factor: 2.967

10.  Important miRs of pathways in different tumor types.

Authors:  Stefan Wuchty; Dolores Arjona; Peter O Bauer
Journal:  PLoS Comput Biol       Date:  2013-01-24       Impact factor: 4.475
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