Literature DB >> 20216929

The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart.

Laura R La Bonte1, Betsy Dokken, Grace Davis-Gorman, Gregory L Stahl, Paul F McDonagh.   

Abstract

The severity of ischaemic heart disease is markedly enhanced in type 2 diabetes. We recently reported that complement activation exacerbates I/R injury in the type 2 diabetic heart. The purpose of this study was to isolate and examine MBL pathway activation following I/R injury in the diabetic heart. ZLC and ZDF rats underwent 30 minutes of left coronary artery occlusion followed by 120 minutes of reperfusion. Two different groups of ZDF rats were treated with either FUT-175, a broad complement inhibitor, or P2D5, a monoclonal antibody raised against rat MBL-A. ZDF rats treated with FUT175 and P2D5 had significantly decreased myocardial infarct size, C3 deposition and neutrophil accumulation compared with untreated ZDF controls. Taken together, these findings indicate that the MBL pathway plays a key role in the severity of complement-mediated I/R injury in the type 2 diabetic heart.

Entities:  

Keywords:  Zucker Diabetic Fatty rat; complement; inflammation; ischaemia-reperfusion injury

Mesh：

Substances：

Year:  2009        PMID： 20216929      PMCID： PMC2834312          DOI： 10.1177/1479164109336051

Source DB:  PubMed          Journal:  Diab Vasc Dis Res        ISSN： 1479-1641            Impact factor:   3.291


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Review 6.  Recent advances into the role of pattern recognition receptors in transplantation.

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Authors:  Miklós Káplár; Shah Sweni; Julianna Kulcsár; Barbara Cogoi; Regina Esze; Sándor Somodi; Mária Papp; László Oláh; Mária Tünde Magyar; Katalin Szabó; Katalin Réka Czuriga-Kovács; Jolán Hársfalvi; György Paragh
Journal:  J Diabetes Res       Date:  2015-11-10       Impact factor: 4.011
  10 in total

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