PURPOSE OF REVIEW: To review and compare the various therapeutic platforms, investigational drugs, and clinical trials targeting geographic atrophy in age-related macular degeneration. RECENT FINDINGS: Investigational agents based on hypothesized causes are being developed to treat geographic atrophy. These platforms are designed to attack the disease on several different fronts. SUMMARY: As knowledge of geographic atrophy pathophysiology advances, targeted pharmacotherapies may well be able to mitigate the retinal damage and vision loss associated with geographic atrophy.
PURPOSE OF REVIEW: To review and compare the various therapeutic platforms, investigational drugs, and clinical trials targeting geographic atrophy in age-related macular degeneration. RECENT FINDINGS: Investigational agents based on hypothesized causes are being developed to treat geographic atrophy. These platforms are designed to attack the disease on several different fronts. SUMMARY: As knowledge of geographic atrophy pathophysiology advances, targeted pharmacotherapies may well be able to mitigate the retinal damage and vision loss associated with geographic atrophy.
Authors: Annal D Meleth; Pradeep Mettu; Elvira Agrón; Emily Y Chew; Srinivas R Sadda; Frederick L Ferris; Wai T Wong Journal: Invest Ophthalmol Vis Sci Date: 2011-02-28 Impact factor: 4.799
Authors: Md Nawajes A Mandal; Gennadiy P Moiseyev; Michael H Elliott; Anne Kasus-Jacobi; Xiaoman Li; Hui Chen; Lixin Zheng; Olga Nikolaeva; Robert A Floyd; Jian-Xing Ma; Robert E Anderson Journal: J Biol Chem Date: 2011-07-24 Impact factor: 5.157
Authors: Audrey B Condren; Anil Kumar; Pradeep Mettu; Katharine J Liang; Lian Zhao; Jen-yue Tsai; Robert N Fariss; Wai T Wong Journal: PLoS One Date: 2013-01-04 Impact factor: 3.240